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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Elsa Lorthe Mathilde Bellon Grégoire Michielin Julie Berthelot María-Eugenia Zaballa Francesco Pennacchio Meriem Bekliz Florian Laubscher Fatemeh Arefi Javier Perez-Saez Andrew S. Azman Arnaud G. L'Huillier Klara M. Posfay-Barbe Laurent Kaiser Idris Guessous Sebastian J. Maerkl Isabella Eckerle Silvia Stringhini |
| Organization | SEROCoV-Schools Study Group |
| Abstract | ObjectivesTo report a prospective epidemiological, virological and serological investigation of a SARS-CoV-2 outbreak in a primary school.MethodsAs part of a longitudinal, prospective, school-based surveillance study, this investigation involved repeated testing of 73 pupils, 9 teachers, 13 non-teaching staff and 26 household members of participants who tested positive, with rapid antigen tests and/or RT-PCR (Day 0-2 and Day 5-7), serologies on dried capillary blood samples (Day 0-2 and Day 30), contact tracing interviews and SARS-CoV-2 whole genome sequencing.ResultsWe identified 20 children (aged 4 to 6 years from 4 school classes), 2 teachers and a total of 4 household members who were infected by the Alpha variant during this outbreak. Infection attack rates were between 11.8 and 62.0% among pupils from the 4 school classes, 22.2% among teachers and 0% among non-teaching staff. Secondary attack rate among household members was 15.4%. Symptoms were reported by 63% of infected children, 100% of teachers and 50% of household members. All analysed sequences but one showed 100% identity. Serological tests detected 8 seroconversions unidentified by SARS-CoV-2 virological tests.ConclusionsThis study confirmed child-to-child and child-to-adult SARS-CoV-2 transmission and introduction into households. Effective measures to limit transmission in schools have the potential to reduce the overall community circulation. |
| e-ISSN | 19326203 |
| DOI | 10.1371/journal.pone.0272663 |
| Journal | PLoS ONE |
| Issue Number | 8 |
| Volume Number | 17 |
| Language | English |
| Publisher | Public Library of Science (PLoS) |
| Publisher Date | 2022-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Medicine Science |
| Content Type | Text |
| Resource Type | Article |
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