NDLI: Medication regimen complexity and its association with adherence and blood pressure control among hypertensive patients at selected hospitals of South Gondar Zone: A hospital based cross sectional study.

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Taklo Simeneh Yazie Workneh Ebabu Mengistu Zemen Asmare Abebe Muche Belete Assefa Agegnehu Teshome Yohannes Shumet Yimer
Abstract	IntroductionDespite the availability of effective antihypertensive medications, blood pressure (BP) control is suboptimal. High medication regimen complexity index (MRCI) is known to reduce adherence and may be the reason for poor BP control. However, there is no data in the present study areas. Hence, the aim of this study was to assess MRCI and its association with adherence and BP control among hypertensive patients at selected hospitals of South Gondar Zone.MethodsA hospital based cross sectional study was conducted from December 1, 2020 to February 30, 2021 at selected hospitals of South Gondar Zone. Medication regimen complexity and adherence was evaluated using 65-item validated tool called MRCI and eight items Morisky Medication Adherence, respectively. Multivariable logistic regression analysis was done to determine the association between predictive and outcome variables.ResultsAbout 3.3% of participants were classified as having high HTN specific MRCI whereas 34.75% of participants were classified as having high patient level MRCI. Among participants, 37.8% were adherent to their medications, and 52.2% of respondents were categorized as having controlled BP. Multivariate logistic regression showed being married, and having lower education level was more likely and less likely to be adherent, respectively. Being illiterate, and having low HTN MRCI were more likely to have controlled BP in adjusted analyses. On the contrary, being non-adherent, not having health insurance, and having lower monthly income were less likely to have controlled BP.ConclusionA considerable proportion of patients had high MRCI. Having low HTN MRCI was more likely to have controlled BP. Simplification of a complex medication regimen for patients with HTN should be sought by physicians and pharmacists to improve BP control.
e-ISSN	19326203
DOI	10.1371/journal.pone.0272717
Journal	PLoS ONE
Issue Number	8
Volume Number	17
Language	English
Publisher	Public Library of Science (PLoS)
Publisher Date	2022-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Medicine Science
Content Type	Text
Resource Type	Article

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