NDLI: Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT

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Potential Applications of Nanotechnology for the Diagnosis and Treatment of Pancreatic Cancer

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

Principles of agonist recognition in Cys-loop receptors

"Drug Resistance Associated Membrane Proteins"

Carotid body, insulin and metabolic diseases: unravelling the links

Far red/near infrared light-induced protection against cardiac ischemia and reperfusion injury remains intact under diabetic conditions and is independent of nitric oxide synthase

Angiotensin II-Induced Endothelial Dysfunction is Temporally Linked with Increases in Intereukin-6 and Vascular Macrophage Accumulation

Systematic review of near-infrared spectroscopy determined cerebral oxygenation during non-cardiac surgery

Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects

Expression pattern of arenicins - the antimicrobial peptides of polychaete Arenicolamarina

Task-dependent inhibition of slow-twitch soleus and excitation of fast-twitch gastrocnemius do not require high movement speed and velocity-dependent sensory feedback

Bending and Twisting the Embryonic Heart: A Computational Model for C-Looping Based on Realistic Geometry

Regulation and roles of bicarbonate transport in cancer

A metabolic link to skeletal muscle wasting and regeneration

What is chronic cough in children?

Ethanol modulation of mammalian BK channels in excitable tissues: molecular targets and their possible contribution to alcohol-induced altered behavior

RESTING SYMPATHETIC BAROREFLEX SENSITIVITY IN SUBJECTS WITH LOW AND HIGH TOLERANCE TO CENTRAL HYPOVOLEMIA INDUCED BY LOWER BODY NEGATIVE PRESSURE

Evaluation and integration of disparate classification systems for clefts of the lip

Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganisation in solid cancers

O2 supplementation to secure the near-infrared spectroscopy determined brain and muscle oxygenation in vascular surgical patients: a presentation of 100 cases

Arterial pressure and cerebral blood flow variability: friend or foe? A review

Local Delivery of Fluorescent Dye For Fiber-Optics Confocal Microscopy of the Living Heart

STIM and Orai isoform expression in pregnant human myometrium: a potential role in calcium signaling during pregnancy.

Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice

The effect of a peer on VO2 and game choice in 6-10 year old children

The Impact of Age-Related Dysregulation of the Angiotensin System on Mitochondrial Redox Balance

Inhibition does not affect the timing code for vocalizations in the mouse auditory midbrain

Antioxidant dilemma: Are they potentially immune suppressant and carcinogen?

Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase C gamma that causes spinocerebellar ataxia type 14

Corrigendum: Vascular development and hemodynamic force in the mouse yolk sac

The location of energetic compartments affects energetic communication in cardiomyocytes

Roles of gap junctions, connexins and pannexins in epilepsy

Structure-function of proteins interacting with the alpha1 pore-forming subunit of high voltage-activated calcium channel

Recent advances in the involvement of long non-coding RNAs in neural stem cell biology and brain pathophysiology

Molecular pathways of pannexin1-mediated neurotoxicity

Calcium-Activated Potassium Channels in Ischemia Reperfusion: A Brief Update

Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents

Skeletal muscle myofilament adaptations to aging, disease and disuse and their effects on whole muscle performance in older adult humans

Spiral-Wave Dynamics in Ionically Realistic MathematicalModels for Human Ventricular Tissue: The Effects of PeriodicDeformation

The impact of vitamin D in breast cancer: genomics, pathways, metabolism

Calcium homeostasis in red blood cells of dialysis patients   in dependence of erythropoietin treatment

Mating changes the female dietary preference in the two-spotted cricket, Gryllus bimaculatus

A deficiency of apoptosis inducing factor (AIF) in Harlequin mouse heart mitochondria paradoxically reduces ROS generation during ischemia-reperfusion

Epigenetic features in the oyster Crassostrea gigas suggestive of functionally relevant promoter DNA methylation in invertebrates.

The Pleural Mesothelium in Development and Disease

Origin and spatiotemporal dynamics of the peroxisomal endomembrane system

Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS): The essence of objective assessment, accurate diagnosis, and acknowledging biological and clinical subgroups.

How man-made interference might cause gas bubble emboli in deep diving whales

Syncope: epidemiology, etiology and prognosis.

Non-Chemical Distant Cellular Interactions as a potential confounder of Cell Biology Experiments

Membrane Nanotubes between peritoneal mesothelial cells: functional connectivity and crucial participation during inflammatory reactions

Macrophages in Homeostatic Immune Function

The 'Goldilocks Zone' from a redox perspective - Adaptive versus deleterious responses to oxidative stress in striated muscle

ROLE OF THE INTERCALATED DISC IN CARDIAC PROPAGATION AND ARRHYTHMOGENESIS

Inflammatory therapeutic targets in coronary atherosclerosis – from molecular biology to clinical application

How to measure propagation velocity in cardiac tissue: a simulation study

DNA Methylation and Temperature Stress in an Antarctic Polychaete, Spiophanes tcherniai

Cardiac mitochondria exhibit dynamic functional clustering

The large conductance Ca2+ -activated K+ (BKCa) channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases

Insect prophenoloxidase: the view beyond immunity

Stimulation of the Basal and Central Amygdala in the Mustached Bat Triggers Echolocation and Agonistic Vocalizations within Multimodal Output

Of macrophages and red blood cells; a complex love story.

The banana code – Natural blend processing in the olfactory circuitry of Drosophila melanogaster

Decoding Dynamic Ca2+ Signaling in the Vascular Endothelium

Introduction to the Research Topic: The Role of Physical Fitness on Cardiovascular Responses to Stress

Autonomic Dysfunction in Muscular Dystrophy: A Theoretical Framework for Muscle Reflex Involvement

Congenital heart malformations induced by hemodynamic altering surgical interventions

Functional insights into modulation of $BK_{Ca}$ channel activity to alter myometrial contractility

Parasympathetic preganglionic cardiac motoneurons labeled after voluntary diving

Adventitial inflammation and its interaction with intimal atherosclerotic lesions

Acidosis slows electrical conduction through the atrio-ventricular node

The contribution of the genomes of a termite and a locust to our understanding of insect neuropeptides and neurohormones

Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise

PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Is recovery driven by central or peripheral factors? A role for the brain in recovery following intermittent-sprint exercise.

Intraperitoneal Bilirubin Administration Decreases Infarct Area in a Rat Coronary Ischemia/Reperfusion Model

Vitamin D and gene networks in human osteoblasts

Self-Measure of heart rate variability (HRV) & arrhythmia to monitor and to manage atrial arrhythmias: Personal experience with high intensity interval exercise (HIIE) for the conversion to sinus rhythm

Physical activity in the prevention of peripheral artery disease in the elderly

Stem cell sources for tooth regeneration: current status and future prospects

Capturing structure and function in an embryonic heart with Biophotonic tools

Adrenal adrenoceptors in heart failure

ABC transporters in fish species: a review

Proteomic approaches for the study of tissue specific effects of 3,5,3'-triiodo-L-thyronine and 3,5-diiodo-L-thyronine in conditions of altered energy metabolism.

Control elements targeting Tgfb3 expression to the palatal epithelium are located intergenically and in introns of the upstream Ift43 gene

Gap junction modulation and its implications for heart function

Functional cardiac imaging by random access microscopy

Sympathetic dysfunction in vasovagal syncope and the postural orthostatic tachycardia syndrome

Influence of intranasal and carotid cooling on cerebral temperature balance and oxygenation

Altered cross-bridge properties in skeletal muscle dystrophies

Mechanical Regulation of Cardiac Development

Insulin signaling pathways in lepidopteran steroidogenesis

REACTIVE OXYGEN SPECIES AT THE CROSSROADS OF INFLAMMASOME AND INFLAMMATION

The flexible structure of the K24S28 region of Leucine-Rich Amelogenin Protein (LRAP) bound to apatites as a function of surface type, calcium, mutation, and ionic strength

Biosonar resolving power: Echo-acoustic perception of surface structures in the submillimeter range

Utilizing Past and Present Mouse Systems to Engineer More Relevant Pancreatic Cancer Models

Overexpression of dilp2 causes nutrient-dependent semi-lethality in Drosophila

Role of sympathetic nerve activity in the process of fainting

Circadian Influences on Myocardial Infarction

Wavelet-based multifractal analysis of dynamic infrared thermograms to assist in early breast cancer diagnosis

Influence of Regular Exercise Training on Post-exercise Hemodynamic Regulation to Orthostatic Challenge

STRUCTURAL ALTERATIONS OF SKELETAL MUSCLE IN COPD

Functional sympatholysis and sympathetic escape in a theoretical model for blood flow regulation

The future of vitamin D analogs

Systemic and renal oxidative stress in the pathogenesis of hypertension: modulation of long-term control of arterial blood pressure by resveratrol.

Helium ion microscopy of enamel crystallites and extracellular tooth enamel matrix

The emerging roles of ribosome biogenesis in craniofacial development

Evidence linking oxidative stress, mitochondrial dysfunction and inflammation in the brain of individuals with autism

The involvement of cation leaks in the storage lesion of red blood cells.

β3-ADRENOCEPTORS INHIBIT STIMULATED NOREPINEPHRINE RELEASE IN SPONTANEOUSLY HYPERTENSIVE RATS

Intercellular Communication in Malignant Pleural Mesothelioma: Properties of Tunneling Nanotubes

Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness

Neurochemical and electrical modulation of the Locus coeruleus: contribution to CO2 drive to breathe

Impact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice

Measuring brain temperature without a thermometer

Ginseng ginsenoside pharmacology in nervous systems: involvement of the regulations of ion channels and receptors

Analysis of enamel development using murine model systems: approaches and limitations.

Update on 3-iodothyronamine and its neurological and metabolic actions

Neuronal and hormonal perturbations in postural tachycardia syndrome

Blue LEDs get the Nobel Prize while Red LEDs are poised to save lives

The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation

Time computations in anuran auditory systems

Modulation of TonEBP activity by SUMO modification in response to hypertonicity

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Muscle metabolic remodelling in response to endurance exercise in salmonids

Regulation of BK channels by auxiliary γ subunits

Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells

Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease.

Modelling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species– pharmacokinetic and therapeutic implications

Glucose sensing by carotid body glomus cells: potential implications in disease

Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton

A structural view of ligand-dependent activation in thermoTRP channels

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Histone content increases in differentiating Embryonic Stem Cells.

Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy

Corrigendum: A quantitative perspective to the study of brain arterial remodeling of donors with and without HIV in the Brain Arterial Remodeling Study (BARS).

S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels

Cerebral oxygenation in health and disease states

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin

Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

Effects of exercise on cardiovascular performance in the elderly

AUTONOMIC REGULATION IN MUSCULAR DYSTROPHY

Expression pattern of glycoside hydrolase genes in Lutzomyia longipalpis reveals key enzymes involved in larval digestion

Correlative intravital imaging of cGMP signals and vasodilation in mice

The regulation of angiogenesis by tissue cell-macrophage interactions

Regional heterogeneity in muscle fiber strain: The role of fiber architecture

Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia

Time-Domain Analysis of Scrotal Thermoregulatory Impairment in Varicocele

LETM1 in mitochondrial cation transport

Investigating the role of uncoupling of Troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of Cardiomyopathy

Cardiac tissue engineering: a reflection after a decade of hurry

Editorial: recent advances in pancreatology

NATIVE EXTRACELLULAR MATRIX: A NEW SCAFFOLDING PLATFORM FOR REPAIR OF DAMAGED MUSCLE

A critical reflection on the principles of peroxisome formation in yeast

NFAT5-mediated expression of S100A4 contributes to proliferation and migration of renal carcinoma cells

3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering

PROLIFERATION VERSUS REGENERATION: THE GOOD, THE BAD AND THE UGLY

Is isolated systolic hypertension an indication for renal denervation?

Fractal analysis of the structural complexity of the connective tissue in human carotid bodies

Coronary Computed Tomography Angiography and Cardiac Magnetic Resonance for Clinical Imaging of Coronary Artery Disease. Diagnostic Classification and Risk Stratification.

From gene to protein - experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Beyond cellular detoxification: A plethora of physiological roles for MDR transporter homologs in plants

Endothelial Dysfunction and Preeclampsia: Role of Oxidative Stress

Oscillatory behaviour of ventricular action potential duration in heart failure patients at respiratory rate and low frequency

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

Association of cancer history with Alzheimer's disease onset and structural brain changes

Optically gated beating-heart imaging

The role of local renin-angiotensin system in arterial chemoreceptors in sleep-breathing disorders

Hemichannels: new roles in astroglial function

Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives

Hormonal regulation of the hypothalamic melanocortin system

Investigating developmental cardiovascular biomechanics and the origins of congenital heart defects

Revisiting cAMP signaling in the carotid body

Grape seed extracts inhibit dentin matrix degradation by MMP-3

Petrosal Ganglion: a more complex role than originally imagined.

Gap Junctions in C. elegans

Tumour suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalling

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease

Micron-scale voltage and [Ca2+]i imaging in the intact heart

Advancements in stem cells treatment of skeletal muscle wasting

The betaine/GABA transporter and betaine: roles in brain, kidney and liver

CHROMus: the Cornell/National Heart Lung Blood Institute Resource for optogenetic mice

Cardiac looping may be driven by compressive loads resulting from unequal growth of the heart and pericardial cavity. Observations on a physical simulation model

Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise

Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy

Preferential and selective degradation and removal of amelogenin adsorbed on hydroxyapatites by MMP20 and KLK4 in vitro

Genome-wide profiling of DNA methylation and gene expression in Crassostrea gigas male gametes

Diabetes, pancreatic cancer, and metformin therapy

Electromyographic, cerebral and muscle hemodynamic responses during intermittent, isometric contractions of the biceps brachii at three submaximal intensities

Analysis of Co-assembly and Co-localization of Ameloblastin and Amelogenin

Dietary glucose regulates yeast consumption in adult Drosophila males

Molecular and cell-based therapies for muscle degenerations: a road under construction

Influence of drugs on gap junctions in glioma cell lines and primary astrocytes in vitro

Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts

Intermittent hypoxic resistance training: does it provide added benefit?

Surveying the floodgates: Estimating protein flux into the endoplasmic reticulum lumen in Saccharomyces cerevisiae

Is CRT Pro-arrhythmic? A Comparative Analysis of The Occurrence of Ventricular Arrhythmias Between Patients Implanted With CRTs and ICDs

Role of [Ca2+]i and F-actin on mesothelial barrier function

The mechanisms of involvement of IL-1 molecules in tumor-mediated angiogenesis

A Multistep Procedure To Prepare Pre-Vascularized Cardiac Tissue Constructs Using Adult Stem Sells, Dynamic Cell Cultures And Porous Scaffolds

Origins and consequences of hyperosmolar stress in retinal pigmented epithelial cells

Ca2+ signaling in arterioles and small arteries of conscious, restrained optical biosensor mice

Simulating Photon Scattering Effects in Structurally Detailed Ventricular Models Using a Monte Carlo Approach

Role of the bicarbonate-responsive soluble adenylyl cyclase in pH sensing and metabolic regulation

Exercise economy in skiing and running

Mega roles of microRNAs in regulation of skeletal muscle health and disease

Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise

Platelets and their chemokines in atherosclerosis – clinical applications

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

The physiology of vitamin D – far more than calcium and bone

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury

A role for the lateral parabrachial nucleus in cardiovascular function and fluid homeostasis

Vitamin D and adipose tissue - more than storage

Malarial pathocoenosis: beneficial and deleterious interactions between malaria and other human diseases

THE BUFFER CAPACITY OF AIRWAY EPITHELIAL SECRETIONS

TRADITIONAL GAMES RESULTED IN POST-EXERCISE HYPOTENSION AND A LOWER CARDIOVASCULAR RESPONSE TO THE COLD PRESSOR TEST IN HEALTHY CHILDREN

The regulation of BK channel activity by pre- and post-translational modifications

Expression of the prostaglandin F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm labour

O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle

Remineralisation and repair of enamel surface by biomimetic Zn-carbonate hydroxyapatite containing toothpaste: A comparative in vivo study

Does regulation of skeletal muscle function involve circulating microRNAs?

Exposure to hot and cold environmental conditions does not affect the decision making ability of soccer referees following an intermittent sprint protocol.

Disparities in the Consequences of Sarcopenia: Implications for African American Veterans

Pancreatic cancer cachexia: A review of mechanisms and therapeutics

Roles of nonmyogenic mesenchymal progenitors in pathogenesis and regeneration of skeletal muscle

Effects of aging on the association between cerebrovascular responses to visual stimulation, hypercapnia and arterial stiffness

Cholesterol binding to ion channels

Bcl-xL in neuroprotection and plasticity

Dynamics of Propagation of Premature Impulses in Structurally Remodeled Infarcted Myocardium: A Computational Analysis

An emerging need for developing new models for myocardial infarction as a chronic complex disease:Lessons learnt from animal vs human studies on cardioprotective effects of Erythropoietin in reperfused myocardium

Effect of contraction intensity on sympathetic nerve activity to active human skeletal muscle

Mitochondria, Endothelial Cell Function and Vascular Diseases

Neocytolysis: none, one or many? A reappraisal and future perspectives

Arterial pressure variations as parameters of brain perfusion in response to central blood volume depletion and repletion

Polarized training has greater impact on key endurance variables than threshold, high intensity or high volume training

The role of sense of effort on self-selected cycling power output

Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation

New roles for old enzymes: killer caspases as the engine of cell behaviour changes

Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban – an oral, direct Factor Xa inhibitor

The Pannexins: Past and Present

Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function

Evolution and physiology of neural oxygen sensing

Angiogenesis as a novel therapeutic strategy for Duchenne muscular dystrophy through decreased ischemia and increased satellite cells

Mitochondrial and cellular mechanisms for managing lipid excess

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

The development of complex tooth shape in reptiles

A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements

Muscle acellular scaffold as a biomaterial: effects on C2C12 cell differentiation andinteraction with the murine host environment

Impact of vitamin D on immune function: lessons learned from genome-wide analysis

The adrenergic system in cardiovascular pathophysiology: a translational science point of view.

Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease

Inflation and deflation pressure-volume loops in anesthetized pinnipeds confirms compliant chest and lungs

Second Hand Smoke and COPD: Lessons From Animal Studies

RED BLOOD CELL, HEMOGLOBIN AND HEME IN THE PROGRESSION OF ATHEROSCLEROSIS

Maturation and beyond: proteins in the developmental continuum from enamel epithelium to junctional epithelium

Plasmacytoid dendritic cells: Development, functions, and role in atherosclerotic inflammation

Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy – New hopes for treatment of musculoskeletal diseases

Plant volatile eliciting FACs in lepidopteran caterpillars, fruit flies and crickets: a convergent evolution or phylogenetic inheritance?

Low-Level Laser Therapy as a Treatment for Chronic Pain

Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury

A N-terminal Truncated Intracellular Isoform of Matrix Metalloproteinase-2 Impairs Contractility of Mouse Myocardium

Everything Hertz: methodological issues in short-term frequency-domain HRV

Regular exercise is associated with emotional resilience to acute stress in healthy adults

Cricket antennae shorten when bending (Acheta domesticus L.)

Spatial distributions at equilibrium under heterogeneous transient subdiffusion

Tight junction physiology of pleural mesothelium

Effect of an anti-human Co-029/tspan8/Tspan8 mouse monoclonal antibody on tumour growth in a nude mouse model

Reactive oxygen species and redox compartmentalization

Breakpoints in Ventilation, Cerebral and Muscle Oxygenation, and Muscle Activity During an Incremental Cycling Exercise

The Role of Pannexin Hemichannels in Inflammation and Regeneration

Role of Pancreatic Stellate Cells in Chemoresistance in Pancreatic Cancer

Primitive and definitive erythropoiesis in mammals

Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle

Specific and quantitative labeling of biomolecules using click chemistry

A comment on Measuring fractality by Stadnitski (2012)

Gene Regulation, Alternative Splicing, and Posttranslational Modification of Troponin Subunits in Cardiac Development and Adaptation: A Focused Review

Time and timing in the acoustic recognition system of crickets

External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster

INWARD RECTIFIERS AND THEIR REGULATION BY ENDOGENOUS POLYAMINES

Identification of novel vibration- and deflection-sensitive neuronal subgroups in Johnston's organ of the fruit fly

Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts

The Effect of Trichostatin-A and Tumour Necrosis Factor on Expression of Splice Variants of the MaxiK and L-Type Channels in Human Myometrium

Detection of the electromechanical delay and its components during voluntary isometric contraction of the quadriceps femoris muscle

Genetic Determinants and Potential Therapeutic Targets for Pancreatic Adenocarcinoma

Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality – an experimental study on the FINCAVAS cohort

Pannexin 1 channels in skeletal muscles

Complex oscillatory redox dynamics with signaling potential at the edge between normal and pathological mitochondrial function

Hypothesis and theory: Mechanical instabilities and non-uniformities in hereditary sarcomere myopathies

Na+ current expression in human atrial myofibroblasts:identity and functional roles

Damage from dissection is associated with reduced neuro-musclar transmission and gap junction coupling between circular muscle cells of guinea pig ileum, in vitro.

Cerebral oxygenation and hyperthermia

Is capacitive coupling purely excitatory in the cardiac tissue?

Soluble proteins of chemical communication: an overview across arthropods

Membrane-myofibril cross-talk in myofibrillogenesis: lessons from the zebrafish

Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

Distribution of the amelogenin protein in developing, injured and carious human teeth

Functional analysis and regulation of purified connexin hemichannels

Regulation of red cell life-span, erythropoiesis, senescence and clearance

Ischemia/reperfusion activates myocardial innate immune response: the key role of the toll-like receptor

The Role of Vitamin D in Skeletal and Cardiac Muscle Function

Membrane domain formation – a key factor for targeted intracellular drug delivery

Quantifying distortions in two-photon remote focussing images using a volumetric calibration specimen

Change in network connectivity during fictive-gasping generation in hypoxia: Prevention by a metabolic intermediate

Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders

Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication

Genetic evidence for conserved non-coding element function across species--the ears have it

BK channel activators and their therapeutic perspectives

Dichotic sound localization properties of duration-tuned neurons in the IC of the big brown bat

The impact of flow-induced forces on the morphogenesis of the outflow tract

Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways

Interaction of vitamin D with membrane-based signaling pathways

METABOLISM LEAVES ITS MARK ON THE POWERHOUSE: RECENT PROGRESS IN POST-TRANSLATIONAL MODIFICATIONS OF LYSINE IN MITOCHONDRIA

Vitamin D and the RNA transcriptome: more than mRNA regulation

Social interactions affecting caste development through physiological actions in termites

Neurohumoral mechanisms associated with orthostasis: Reaffirmation of the significant contribution of the heart rate response

CAROTID BODY POTENTIATION DURING CHRONIC INTERMITTENT HYPOXIA: IMPLICATION FOR HYPERTENSION

Aphid Polyphenisms: Trans-generational Developmental Regulation through Viviparity

Potential of caveolae in the therapy of cardiovascular and neurological diseases

Phosphorylation of BK channels modulates the sensitivity to hydrogen sulfide (H2S)

In the carotid body, galanin is a signal for neurogenesis in young, and for neurodegeneration in the old and in drug-addicted subjects

Monitoring training status with HR measures: do all roads lead to Rome?

Towards panoramic in situ mapping of action potential propagation in transgenic hearts to investigate initiation and therapeutic control of arrhythmias

Ventilatory strategy during liver transplantation: implications for near-infrared spectroscopy-determined frontal lobe oxygenation

Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells

Lipid regulation of BK channel function

Transcriptome analysis of host-associated differentiation in Bemisia tabaci (Hemiptera: Aleyrodidae)

The role of DNA methylation on Octopus vulgaris development and their perspectives

Polyubiquitin chain assembly and organisation determine the dynamics of protein activation and degradation

Creatine transporter (SLC6A8) knock out mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle

The role of the BK channel in ethanol response behaviors: evidence from model organism and human studies.

Effect of phenylephrine vs. ephedrine on frontal lobe oxygenation during caesarean section with spinal anaesthesia: An open label randomised controlled trial

Advances in Systems Immunology and Cancer

Assessing uncertainty in model parameters based on sparse and noisy experimental data

Glycopyrrolate does not influence the visual or motor induced increase in regional cerebral perfusion

Four-way regulation of mosquito yolk protein precursor genes by juvenile hormone-, ecdysone-, nutrient-, and insulin-like peptide signaling pathways

Functional roles of Na+/K+-ATPase in active ammonia excretion and seawater acclimation in the giant mudskipper, Periophthalmodon schlosseri

Correlations and coherence of monopolar EMG-currents of the medial gastrocnemius muscle in proximal and distal compartments

Comparison of Two Mouse Ameloblast-like Cell Lines for Enamel-specific Gene Expression

Case report: (Pre)syncopal symptoms associated with a negative internal jugular venous pressure

2.1. Structural considerations of vitamin D signaling

Involvement of gap junction channels in the pathophysiology of migraine with aura

An Evo-Devo perspective on ever-growing teeth in mammals and dental stem cell maintenance

Connexin hemichannels in the lens

Patient stratification and identification of adverse event correlations in the space of 1,190 drug related adverse reactions

Emerging Trend In Second Messenger Communication And Myoendothelial Feedback

STARS AND STRIPES IN PANCREATIC CANCER: ROLE OF STELLATE CELLS AND STROMA IN CANCER PROGRESSION

Expression analysis of candidate genes regulating successional tooth formation in the human embryo

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

Increases in Oscillatory Cerebral Blood Flow Velocity in Postural Tachycardia Syndrome

Skeletal muscle pathology in Huntington's Disease.

Eicosapentaenoic acid attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling

From Bedside to Bench and back again – Molecular Mechanisms in Acute Liver Failure

Molecular and neural mechanisms of sex pheromone reception and processing in the silkmoth Bombyx mori

Hemichannels; from the molecule to the function

Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT

FGF2 activates TRPC and Ca2+ signaling leading to satellite cell activation.

Alterations in thin filament length during postnatal skeletal muscle development and aging in mice

Adipose tissues and thyroid hormones

Computational modeling of voltage-gated Ca channels inhibition: identification of different effects on uterine and cardiac action potentials

Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations

Receptors for short-chain fatty acids in brush cells at the gastric groove

Pancreatic cancer risk in hereditary pancreatitis

A quantitative perspective to the study of brain arterial remodeling of donors with and without HIV in the Brain Arterial Remodeling Study (BARS).

A 5- Year Comparison of Marginal Bone Level Following Immediate Loading of Single-Tooth Implants Placed in Healed Alveolar Ridges and Extraction Sockets in the Maxilla.

Possible role of hemichannels in cancer.

Low cadence interval training at moderate intensity does not improve cycling performance in highly trained veteran cyclists

Vitamin D: a critical and essential micronutrient for human health

Mindfulness may both moderate and mediate the effect of physical fitness on cardiovascular responses to stress: a speculative hypothesis.

Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells

CLC channel function and dysfunction in health and disease

Ontogenetic changes in skeletal muscle fiber type, fiber diameter and myoglobin concentration in the Northern elephant seal (Mirounga angustirostris)

Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy.

Systems physiology of the baroreflex during orthostatic stress: from animals to humans

To Understand Muscle You Must Take It Apart

Necroptosis: Is There a Role for Mitochondria?

Genome-wide (over)view on the actions of vitamin D

The Expanded Amelogenin Polyproline Region Preferentially Binds to Apatite versus Carbonate and Promotes Apatite Crystal Elongation

Cx43 expression and function in the nervous system - implications for stem cell mediated regeneration

Myocardial hypertrophy reduces transmural variation in mitochondrial function

General Commentary: MicroRNA and Skeletal Muscle Function: Novel Potential Roles in Exercise, Diseases, and Aging.

Targeting diseased tissues by pHLIP insertion at low cell surface pH

Impact and management of physiological calibration in spectral analysis of blood pressure variability

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach

Focal adhesion kinase regulates the activity of the osmosensitive transcription factor TonEBP/NFAT5 under hypertonic conditions

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Greater glucose uptake heterogeneity in knee muscles of old compared to young men during isometric contractions detected by [18F]-FDG PET/CT

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Thorsten eRudroff John H. Kindred John-Michael eBenson Brian L. Tracy Kari K. Kalliokoski
Abstract	We used positron emission tomography/computed tomography (PET/CT) and [18F]-FDG to test the hypothesis that glucose uptake (GU) heterogeneity in skeletal muscles as a measure of heterogeneity in muscle activity is greater in old than young men when they perform isometric contractions. Six young (26 ± 6 yrs) and six old (77 ± 6 yrs) men performed two types of submaximal isometric contractions that required either force or position control. [18F]-FDG was injected during the task and PET/CT scans were performed immediately after the task. Within-muscle heterogeneity of knee muscles was determined by calculating the coefficient of variation (CV) of GU in PET image voxels within the muscles of interest. The average GU heterogeneity (mean ± SD) for knee extensors and flexors was greater for the old (35.3 ± 3.3 %) than the young (28.6 ± 2.4 %) (P = 0.006). Muscle volume of the knee extensors were greater for the young compared to the old men (1016 ± 163 vs. 598 ± 70 cm3, P= 0.004). In a multiple regression model, knee extensor muscle volume was a predictor (partial r = - 0.87; P = 0.001) of GU heterogeneity for old men (R2 = 0.78; P < 0.001), and MVC force predicted GU heterogeneity for young men (partial r = - 0.95, P < 0.001). The findings demonstrate that glucose uptake is more spatially variable for old than young men and especially so for old men who exhibit greater muscle atrophy.
e-ISSN	1664042X
DOI	10.3389/fphys.2014.00198
Journal	Frontiers in Physiology
Volume Number	5
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2014-01-01
Publisher Place	Switzerland
Access Restriction	Open
Subject Keyword	Physiology Aging Glucose Computed Tomography Positron Emission Tomography Muscle Volume
Content Type	Text
Resource Type	Article

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