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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Angélica Fierro Dale E. Edmondson Cristian Celis-Barros Marco Rebolledo-Fuentes Gerald Zapata-Torres |
| Abstract | Despite their structural and chemical commonalities, p-chloro-β-methylphenethylamine and p-methoxy-β-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional Theory (DFT) quantum chemical calculations reveal that β-methylation and para-substitution underpin the observed activities sustained by calculated transition state energy barriers, attained conformations and key differences in their interactions in the enzyme's substrate binding site. Although both compounds meet substrate requirements, it is clear that β-methylation along with the physicochemical features of the para-substituents on the aromatic ring determine the activity of these compounds upon binding to the MAO B-isoform. While data for a larger set of compounds might lend generality to our conclusions, our experimental and theoretical results strongly suggest that the contrasting activities displayed depend on the conformations adopted by these compounds when they bind to the enzyme. |
| e-ISSN | 19326203 |
| DOI | 10.1371/journal.pone.0154989 |
| Journal | PLoS ONE |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | Public Library of Science (PLoS) |
| Publisher Date | 2016-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Science Medicine |
| Content Type | Text |
| Resource Type | Article |
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