NDLI: Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways

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Phellinus linteus grown on germinated brown rice Suppress metastasis and Induce Apoptosis of Colon Cancer Cells by suppressing NF-κB and Wnt/β-catenin Signaling Pathways

Content Provider	Directory of Open Access Journals (DOAJ)
Author	Hye-Jin Park
Abstract	Phellinus linteus is a mushroom with a variety of biological functions, such as antitumor and immunomodulating activities. P. linteus grown on germinated brown rice (PBR) feeding significantly decreased colon cancer metastasis to the lung and overall tumor size. In biomarker analysis, PBR showed significant anti-metastatic, anti-proliferative and pro-apoptotic activities. Detailed mechanistic studies highlighted that PBR strongly modulated MMP-2 and -9 activities and apoptotic biomarkers as well as decreased NF-κB, β-catenin, and mitogen-activated protein kinase (MAPK) expression. Together, these findings suggest that PBR is effective in preventing CRC by suppressing metastasis and proliferation and inducing apoptosis.
Related Links	http://www.sciencedirect.com/science/article/pii/S1756464614004125
ISSN	17564646
e-ISSN	22149414
DOI	10.1016/j.jff.2014.12.033
Journal	Journal of Functional Foods
Volume Number	14
Language	English
Publisher	Elsevier
Publisher Date	2015-01-01
Publisher Place	United Kingdom
Access Restriction	Open
Subject Keyword	Nutrition. Foods and Food Supply Colorectal Cancer Metastasis Pbr Mmp Nf-κb Β-catenin
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine Food Science

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