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Extract of Indian green mussel, Perna viridis (L.) shows inhibition of blood capillary formation in vitro
| Content Provider | CSIR - National Institute of Oceanography (NIO) |
|---|---|
| Author | Mirshahi, M. Mirshahi, P. Negro, S. Soria, J. Sreekumar, P. K. Kotnala, S. Therwath, A. Chatterji, A. |
| Abstract | The extract of the Indian green mussel (Perna viridis L.) was found to inhibit the formation of endothelial cell capillary tube in a concentration dependent manner in vitro. At a concentration of 5 mg/ml of crude extract, there no formation of intercellular junctions and capillary tubes was observed, even after 6 hours. However, at the concentrations below 1 mg/ml, a few cellular junctions and formation of capillaries began to increase at both concentrations of 0.2 and 0.04 mg/ml. The aqueous fraction was also found to inhibit the capillary and junction formations at 5 mg/ml, but it was less effective at lower concentrations, as compared to the total crude extract. The methanol (MeOH) extract was more active than that of the aqueous extract; hence, it was further fractionated into 5 fractions (F1 to F5) and tested for the presence of angiogenic activity. Fraction 3 (F3), which was used at 100 mew g/ml concentration, showed a significant inhibitory effect on the formation of intercellular junctions and tube, whereas the other fractions did not show any activity |
| Starting Page | 35 |
| Ending Page | 42 |
| Page Count | 8 |
| File Format | |
| Journal | Pertanika Journal of Tropical Agricultural Science |
| Issue Number | 1 |
| Volume Number | 32 |
| Language | English |
| Publisher | Universiti Putra Malaysia Press |
| Access Restriction | Authorized |
| Subject Keyword | Marine molluscs Chemical extraction Perna viridis Indian green mussel |
| Content Type | Text |
| Resource Type | Article |
