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A serine protease inhibitor from hemolymph of green mussel, Perna viridis
| Content Provider | CSIR - National Institute of Oceanography (NIO) |
|---|---|
| Author | Khan, M. S. Goswami, U. Rojatkar, S. R. Khan, M. I. |
| Abstract | Bioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor (SPI) showing IC sub(50) and K sub(i) values of 102.5 and 97.1-104.68 mu M, respectively. The E sub(t)/K sub(i) value of SPI is 6.3, whereas E sub(t)/K sub(m) value is 1.04. The Van't Hoff analysis showed that the value of K sub(i) decreases with increase in temperature, and the binding of the inhibitor is entropically driven. |
| Starting Page | 3963 |
| Ending Page | 3967 |
| Page Count | 5 |
| File Format | |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume Number | 18 |
| Language | English |
| Publisher | Elsevier |
| Access Restriction | Authorized |
| Content Type | Text |
| Resource Type | Article |
