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Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family (2001)
| Content Provider | CiteSeerX |
|---|---|
| Author | Mizokami, Masashi Wang, Richard Y. H. Yeo, Anthony E. T. Alter, Harvey J. Primi, Daniele Tanaka, Yasuhito Umemura, Takeji Shih, J. Wai-Kuo |
| Abstract | A new group of transmissible single-stranded (ss) DNA viruses (SENV) distantly related to the large TT virus (TTV) family was recently identi®ed. Eight different SENV isolates have been found, some with an association with posttransfusion hepatitis. A phylogenetic analysis of near-complete open-reading frame 1, including conserved motifs and excluding recombinant regions, was performed. The analysis used TTV-like minivirus as an outgroup, to determine a root of the phylogenetic tree, and compared 8 SENV isolates, 6 prototype TTV isolates, and 7 TTV variants (including SANBAN, TUS01, PMV, and YONBAN). Four distinct clus-ters separated by a bootstrap value of 100 % were observed. YONBAN isolates formed a distinct outer group, representing the earliest recognized phylogenetic divergence (group 1). Prototype TTV formed group 2, PMV formed group 3, and SENV, SANBAN, and TUS01 isolates formed group 4, the most recently evolved group. This taxonomic classi®cation sug-gests that these circular ssDNA viruses probably evolved from a common ancestor virus. Recently, a new family of single-stranded (ss) DNA viruses, distantly related to the TT virus (TTV) [1, 2], was isolated and was designated as SEN virus (SENV), after the initials of the |
| File Format | |
| Journal | J. Infect. Dis |
| Publisher Date | 2001-01-01 |
| Access Restriction | Open |
| Content Type | Text |