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Novel pharmacokinetic measurement using electron paramagnetic resonance spectroscopy and simulation of in vivo decay of various nitroxyl spin probes in mouse blood (2004).
| Content Provider | CiteSeerX |
|---|---|
| Author | Matsumoto, Ken-Ichiro Krishna, Murali C. Mitchell, James B. |
| Abstract | A novel approach to measure the time course of paramagnetic spin probe concentration in the circulating blood of a living mouse using X-band (9.4 GHz) electron paramagnetic reso-nance spectrometer is described. Using this technique, the pharmacokinetics of several nitroxyl spin probes was exam-ined. The decay profiles were also independently simulated using pharmacokinetic properties as well as redox-mediated factors responsible in converting the nitroxyl radicals to the corresponding hydroxylamines. Finally, suitability of nitroxyl radicals as the probes of in vivo redox status and for radiopro-tection was described. The studies indicate that the six-mem-ber piperidine nitroxyls are suitable for estimating redox status in the circulation, whereas the five-member pyrrolidine nitroxyl radicals are suited for tissue redox status determination. For |
| File Format | |
| Publisher Date | 2004-01-01 |
| Access Restriction | Open |
| Subject Keyword | Mouse Blood Various Nitroxyl Spin Probe Vivo Decay Nitroxyl Radical Several Nitroxyl Tissue Redox Status Determination Redox-mediated Factor Five-member Pyrrolidine Nitroxyl Radical Pharmacokinetic Property Paramagnetic Spin Probe Concentration Time Course Living Mouse Novel Approach Paramagnetic Reso-nance Spectrometer Decay Profile Corresponding Hydroxylamines Redox Status Six-mem-ber Piperidine Nitroxyls Vivo Redox Status |
| Content Type | Text |
