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Channel model of second messenger mediated transformation of gaba induced currents.
| Content Provider | CiteSeerX |
|---|---|
| Author | Avrama, Blackwell Blackwell, K. T. |
| Abstract | Hermissenda crassicornis exhibits Pavlovian conditioning in response to repeated presentations of paired light and turbulence stimuli. The behavioral changes are correlated with a change in electrical properties of the B photoreceptor cell. In response to turbulence, the hair cell releases GABA onto the terminal branches of the B cell. After repeated stimulation of the B cell using a light flash paired with GABA, the net GABA induced currents change from inhibitory to excitatory. To investigate the mechanisms underlying the change in GABA induced currents from net inhibitory to net excitatory, channel models of the GABA induced currents are developed. The similarity of measured and modeled currents supports the hypothesis that the transformation of GABA currents depends on second messenger mediated events such as phosphorylation. INTRODUCTION Classical conditioning of Hermissenda crassicornis with paired light and turbulence causes behavioral changes characteristic of classical condi... |
| File Format | |
| Access Restriction | Open |
| Subject Keyword | Channel Model Second Messenger Mediated Transformation Gaba Induced Current Paired Light Behavioral Change Current Change Gaba Current Net Inhibitory Second Messenger Hermissenda Crassicornis Exhibit Pavlovian Conditioning Net Gaba Hair Cell Electrical Property Repeated Stimulation Hermissenda Crassicornis Turbulence Stimulus Introduction Classical Conditioning Net Excitatory Light Flash Classical Condi Terminal Branch Photoreceptor Cell |
| Content Type | Text |
