NDLI: Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

Please wait, while we are loading the content...

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

Content Provider	CiteSeerX
Abstract	The central nervous system has been implicated in the activation of counterregulatory hormone release during hypoglycemia. However, the precise loci involved are not established. To determine the role of the ventromedial hypothalamic nuclei (VMH) in the hormonal response to hypoglycemia, we performed hypoglycemic clamp studies in conscious Sprague-Dawley rats with bilateral VMH lesions produced by local ibotenic acid injection 2 wk earlier. Rats with lesions in the lateral hypothalamic area, frontal lobe, sham operated (stereotaxic needle placement into hypothalamus without injection), and naive animals served as control groups. The clamp study had two phases. For the first hour plasma glucose was fixed by a variable glucose infusion at euglycemia ( 5.9 mM). Thereafter, for an additional 90 min, glucose was either allowed to fall to (a) mild hypoglycemia (- 3.0 mM) or (b) more severe hypoglycemia 2.5 mM). Glucagon and catecholamine responses of lateral hypothalamic area-, frontal lobe-lesioned, sham operated, and naive animals were virtually identical at each hypoglycemic plateau. In contrast, glucagon, epinephrine, and norepinephrine responses in the VMH-lesioned rats were markedly inhibited; hormones were diminished by 50-60 % during mild and by 75-80 % during severe hypoglycemia as compared with the other groups. We conclude that the VMH plays a crucial role in triggering the release of glucagon and catecholamines during hypoglycemia. (J. Clin. Invest. 1994. 93:1677-
File Format	PDF
Access Restriction	Open
Subject Keyword	Ventromedial Hypothalamic Lesion Rat Suppress Counterregulatory Response Severe Hypoglycemia Naive Animal Lateral Hypothalamic Area Hypoglycemic Clamp Study Variable Glucose Infusion Clamp Study Central Nervous System Counterregulatory Hormone Release Conscious Sprague-dawley Rat Crucial Role Hormonal Response Catecholamine Response Mild Hypoglycemia Precise Locus Ventromedial Hypothalamic Nucleus Local Ibotenic Acid Injection First Hour Plasma Glucose Hypoglycemic Plateau Frontal Lobe Bilateral Vmh Lesion Vmh-lesioned Rat Norepinephrine Response Control Group
Content Type	Text

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in