NDLI: Atp-sensitive potassium channels regulate the release of gaba in the ventromedial (2006).

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Atp-sensitive potassium channels regulate the release of gaba in the ventromedial (2006).

Content Provider	CiteSeerX
Author	Hypoglycemia, Hypothalamus During Chan, Owen Lawson, Marcus Zhu, Wanling Beverly, Joseph Lee Sherwin, Robert S.
Abstract	determine whether alterations in counterregulatory responses to hypoglycemia through the modulation of ATP-sensitive potassium (KATP) channels in the ventromedial hypothalamus (VMH) is mediated by changes in GABAergic inhibitory tone in the VMH, we examined whether opening and closing KATP channels in the VMH alters local GABA levels and if the effects of modulating KATP channel activity within the VMH can be reversed by local modulation of GABA receptors. Research Design and Methods: Rats were cannulated and bilateral guide cannulas were inserted to the level of the VMH. Eight days later, the rats received a VMH microinjection of either 1) vehicle, 2) the KATP channel opener, diazoxide (DZ), 3) the KATP channel closer, glybenclamide (GLYB), 4) DZ + the GABAA receptor agonist, muscimol (MUS) or 5) GLYB + the GABAA receptor antagonist, bicuculline methiodide (BIC) prior to performance of a hypoglycemic clamp. Throughout, VMH GABA levels were measured using microdialysis. Results: As expected, DZ suppressed glucose infusion rates and increased glucagon and epinephrine responses, whereas
File Format	PDF
Publisher Date	2006-01-01
Access Restriction	Open
Subject Keyword	Atp-sensitive Potassium Channel Regulate Research Design Gabaa Receptor Antagonist Atp-sensitive Potassium Epinephrine Response Eight Day Bilateral Guide Cannula Glucose Infusion Rate Katp Channel Closer Vmh Gaba Level Bicuculline Methiodide Hypoglycemic Clamp Counterregulatory Response Vmh Microinjection Local Modulation Ventromedial Hypothalamus Katp Channel Opener Gaba Receptor Vmh Alters Local Gaba Level Gabaergic Inhibitory Tone Closing Katp Channel Katp Channel Activity Gabaa Receptor Agonist
Content Type	Text

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