NDLI: Dopamine D1 receptordependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane (2001)

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Dopamine D1 receptordependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane (2001)

Content Provider	CiteSeerX
Author	Dunah, Anthone W. St, David G.
Abstract	Recent work has shown substantial alterations in NMDA receptor subunit expression, assembly, and phosphorylation in the dopamine-depleted striatum of a rodent 6-hydroxydopamine model of Parkinson’s disease. These modifications are hypothesized to result from the trafficking of NMDA receptors between subcellular compartments. Here we show that in rat striatal tissues the NR2A and NR2B subunits in the synaptosomal membrane, and not those in the light membrane and synaptic vesicle-enriched compartments, are tyrosine phosphorylated. The dopamine D1 receptor agonist SKF-82958 produces (1) an increase in NR1, NR2A, and NR2B proteins in the synaptosomal membrane fraction; (2) a decrease in NR1, NR2A, and NR2B proteins in the light membrane and synaptic vesicleenriched fractions; and (3) an increase in the tyrosine phosphorylation of NR2A and NR2B in the synaptosomal membrane
File Format	PDF
Journal	J. Neurosci
Language	English
Publisher Date	2001-01-01
Access Restriction	Open
Subject Keyword	Postsynaptic Membrane Dopamine D1 Receptordependent Trafficking Striatal Nmda Glutamate Receptor Nr2b Protein Synaptosomal Membrane Light Membrane Synaptic Vesicle-enriched Compartment Nr2b Subunit Dopamine-depleted Striatum Synaptic Vesicleenriched Fraction Tyrosine Phosphorylation Nmda Receptor Subunit Expression Substantial Alteration Subcellular Compartment Nmda Receptor Parkinson Disease Rodent 6-hydroxydopamine Model Synaptosomal Membrane Fraction Dopamine D1 Receptor Agonist Skf-82958 Recent Work
Content Type	Text
Resource Type	Article

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