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The dopamine D1 receptor agonist SKF-82958 effectively increases eye blinking count in common marmosets
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kotani, Manato Kiyoshi, Akihiko Murai, Takeshi Nakako, Tomokazu Ikeda, Kazuhito |
| Copyright Year | 2016 |
| Abstract | Eye blinking is a spontaneous behavior observed in all mammals, and has been used as a well-established clinical indicator for dopamine production in neuropsychiatric disorders, including Parkinson's disease and Tourette syndrome [1,2]. Pharmacological studies in humans and non-human primates have shown that dopamine agonists/antagonists increase/decrease eye blinking rate. Common marmosets (Callithrix jacchus) have recently attracted a great deal of attention as suitable experimental animals in the psychoneurological field due to their more developed prefrontal cortex than rodents, easy handling compare to other non-human primates, and requirement for small amounts of test drugs. In this study, we evaluated the effects of dopamine D1-4 receptors agonists on eye blinking in common marmosets. Our results show that the dopamine D1 receptor agonist SKF-82958 and the non-selective dopamine receptor agonist apomorphine significantly increased common marmosets eye blinking count, whereas the dopamine D2 agonist (+)-PHNO and the dopamine D3 receptor agonist (+)-PD-128907 produced somnolence in common marmosets resulting in a decrease in eye blinking count. The dopamine D4 receptor agonists PD-168077 and A-41297 had no effect on common marmosets' eye blinking count. Finally, the dopamine D1 receptor antagonist SCH 39166 completely blocked apomorphine-induced increase in eye blinking count. These results indicate that eye blinking in common marmosets may be a useful tool for in vivo screening of novel dopamine D1 receptor agonists as antipsychotics. |
| Starting Page | 25 |
| Ending Page | 30 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bbr.2015.11.028 |
| PubMed reference number | 26675887 |
| Journal | Medline |
| Volume Number | 300 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S016643281530303X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S016643281530303X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bbr.2015.11.028 |
| Journal | Behavioural Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
