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Synapses are lost during aging in the primate prefrontal cortex (2008)
| Content Provider | CiteSeerX |
|---|---|
| Author | Peters, A. B. C. Sethares, A. J. I. Luebke, A. |
| Abstract | Abstract—An electron microscopic analysis has been carried out on the effects of age on the numerical density of both excitatory (asymmetric) and inhibitory (symmetric) synapses in the neuropil of layers 2/3 and of layer 5 in area 46 from the frontal cortex of behaviorally tested rhesus monkeys. There is no change in the lengths of synaptic junctions with age or in the percentage distribution of synapses relative to the postsynaptic spines and dendritic shafts. However, in layers 2/3 there is an overall loss of about 30 % of synapses from 5 to 30 years of age, and both asymmetric and symmetric synapses are lost at the same rate. In layer 5 the situation is different; the overall loss of synapses is only 20 % and this is almost entirely due to a loss of asymmetric synapses, since there is no significant loss of symmetric synapses from this layer with age. When the synapse data are correlated with the |
| File Format | |
| Journal | Neuroscience |
| Language | English |
| Publisher Date | 2008-01-01 |
| Access Restriction | Open |
| Subject Keyword | Primate Prefrontal Cortex Overall Loss Symmetric Synapsis Synaptic Junction Postsynaptic Spine Electron Microscopic Analysis Asymmetric Synapsis Rhesus Monkey Significant Loss Numerical Density Percentage Distribution Synapse Data Frontal Cortex Dendritic Shaft |
| Content Type | Text |
| Resource Type | Article |
