Loss of asymmetric spine synapses in dorsolateral prefrontal cortex of cognitively impaired phencyclidine-treated monkeys

Content Provider	Scilit
Author	Elsworth, John D. Hajszan, Tibor Leranth, Csaba Roth, Robert H.
Copyright Year	2011
Description	Schizophrenia patients, long-term abusers of phencyclidine (PCP), and monkeys treated with PCP all exhibit enduring cognitive deficits. Evidence indicates that loss of prefrontal cortex spine synapses results in cognitive dysfunction, suggesting the presence of synaptic pathology in the monkey PCP model; however, there is no direct evidence of such changes. In this study we use the monkey PCP model of schizophrenia to investigate at the ultrastructural level whether remodelling of dorsolateral prefrontal cortex (DLPFC) asymmetric spine synapses occurs following PCP. Subchronic PCP treatment resulted in a decrease in the number of asymmetric spine synapses, which was greater in layer II/III than layer V of DLPFC, compared to vehicle-treated controls. This decrease may contribute to PCP-induced cognitive dysfunction in the non-human primate model and perhaps in schizophrenia. Thus, the synapse loss in the PCP model provides a novel target for the development of potential treatments of cognitive dysfunction in this model and in schizophrenia.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399728/pdf https://academic.oup.com/ijnp/article-pdf/14/10/1411/2264026/14-10-1411.pdf
Ending Page	1415
Page Count	5
Starting Page	1411
DOI	10.1017/s1461145711000939
Journal	International Journal of Neuropsychopharmacology
Issue Number	10
Volume Number	14
Language	English
Publisher	Cambridge University Press (CUP)
Publisher Date	2011-11-01
Access Restriction	Open
Subject Keyword	International Journal of Neuropsychopharmacology Behavioral Sciences Asymmetric Synapse Prefrontal Cortex Electron Microscopy
Content Type	Text
Resource Type	Article