NDLI: Designing Body-Part Templates for Regeneration

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Peter, X. Ma
Copyright Year	2006
Abstract	Tissue losses and organ failures result in more than 8 million surgical procedures each year in the United States. Current therapies for these disorders are seriously limited. Our laboratory takes a biomimetic approach to design polymers into body-part templates (scaffolds) to engineer tissues/organs. The scaffolds are designed to take the form of the missing/damaged body parts, to mimic certain advantageous aspects of natural extracellular matrix, and to contain certain designed structural features to enhance tissue regeneration. To mimic bone matrix, biodegradable polymer/nano-hydroxyapatite composite scaffolds have been developed. To mimic the nano-fibrous architecture of collagen, synthetic nano-fibrous scaffolds have been developed. To optimize scaffolding function, a variety of macropore networks have been designed in the nano-fibrous materials. These novel nano-structured scaffolds enhance cell adhesion and function. Surface engineering and biological delivery in the nano-fibrous scaffolds are shown to improve cellular interactions and tissue formation. These experimental results demonstrate that the biomimetic template design is a powerful approach for tissue regeneration.
Sponsorship	Manufacturing Engineering Division
Starting Page	345
Ending Page	348
Page Count	4
File Format	PDF
ISBN	0791847624
DOI	10.1115/MSEC2006-21042
e-ISBN	0791837868
Volume Number	Manufacturing Science and Engineering, Parts A and B
Conference Proceedings	ASME 2006 International Manufacturing Science and Engineering Conference
Language	English
Publisher Date	2006-10-08
Publisher Place	Ypsilanti, Michigan, USA
Access Restriction	Subscribed
Subject Keyword	Biodegradation Biological tissues Adhesion Design Patient treatment Composite materials Biomimetics Surface engineering Surgery Bone Engineers Polymers Failure
Content Type	Text
Resource Type	Article

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