NDLI: Characterizations of Diagnostic Properties and Detection Techniques of Fentanyl and Related Synthetic Opioids

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Characterizations of Diagnostic Properties and Detection Techniques of Fentanyl and Related Synthetic Opioids

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Rahman, M. Shafiqur Uttam, K. Chakravarty
Copyright Year	2018
Abstract	Fentanyl, a synthetic opioid, is an extremely fast-acting synthetic narcotic analgesic having a high potency of approximately 100 to 200 times that of Morphine. As the synthetic opioid crisis continues to sweep across the world, detection technologies are required to be enhanced to detect, categorize, and identify synthetic opioids effectively. To detect fentanyl and its analogues, immunoassay screens are commercially available for urine specimens. Simple colorimetric assays, i.e., spot tests with paper strips, offer speed, simplicity of operation, portability, and affordability. The microfluidic behavior of the paper strips along with the properties of chemical reagents play significant role in drug detection methods. Therefore, the objectives of this study are to characterize the chemical properties of fentanyl and its analogues and to conduct microfluidic analysis for design optimization and performance evaluation of the fentanyl test strips. A computational fluid dynamics model is developed to evaluate the microfluidic properties. Analytical study and Experiments with test-kit samples are also conducted to validate the results of the numerical simulation. Finally, the performance parameters based on microfluidic analysis were reported showing the room for improvements in the detection technology of fentanyl and related synthetic opioids.
File Format	PDF
ISBN	9780791852002
DOI	10.1115/IMECE2018-87803
Volume Number	Volume 1: Advances in Aerospace Technology
Conference Proceedings	ASME 2018 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2018-11-09
Publisher Place	Pittsburgh, Pennsylvania, USA
Access Restriction	Subscribed
Subject Keyword	Design Drugs Performance evaluation Strips Computational fluid dynamics Computer simulation Chemical properties Assaying Microfluidics Optimization
Content Type	Text
Resource Type	Article

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