NDLI: Experimental Assessment of Emitted Dose From Valved Holding Chamber Devices

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Ricardo, F. Oliveira Manuel, V. Silva Ana, V. Machado Oliveira, Manuel Cabral-Marques, Helena Maria Senhorinha, F. Teixeira Teixeira, José Carlos
Copyright Year	2014
Abstract	Due to the increasing worldwide incidence of asthma, a growing usage of inhalation devices has been observed. Some of the pressurized Metered Dose Inhalers (pMDI) limitations have been overcome by the introduction of newly and improved Valved Holding Chambers (VHC), resulting in good patient acceptance. The efficiency is assessed by the VHC Emitted Dose (ED), i.e. the amount of drug available to the patient. Using the pMDI salbutamol sulfate formulation (Ventolin® HFA-134a) as the test drug, several VHC devices were assessed. These latest were grouped by material characteristics: dissipative (OptiChamber Diamond®, AeroChamber Plus®, Vortex®, A2A Spacer®), non-dissipative (SpaceChamber Plus®, Compact SpaceChamber Plus®, Volumatic®) and stainless steel (Nebuchamber®). The pMDI + VHC were assembled to a filter housing, which comprises an induction port with similar USP Throat dimensions, and connected to a vacuum pump (calibrated at 15, 26 and 40 L/min). Using UV-Vis Spectrophotometry equipment at 244 nm, it was possible to determine its concentration for later mass calculation. For all the VHC devices tested, the total mass recovery percentage was between 85% and 120%. At 26 L/min, the Vortex® VHC has shown the highest ED (47.3 ± 1.8 %). The ED may not be dependent on the volume of the VHC. Although, further analysis of the results suggests the existence of a linear correlation between the ED and the VHC body length. SpaceChamber Plus® results show an increase of the ED and, subsequently, a decrease in VHC deposition fraction, with the increase of airflow.
File Format	PDF
ISBN	9780791846469
DOI	10.1115/IMECE2014-38846
Volume Number	Volume 3: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2014 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2014-11-14
Publisher Place	Montreal, Quebec, Canada
Access Restriction	Subscribed
Subject Keyword	Drugs Air flow Filters Electromagnetic induction Stainless steel Vortices Diamonds Dimensions Ultraviolet-visible spectrophotometry Vacuum pumps
Content Type	Text
Resource Type	Article

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