NDLI: Preparation and Characterization of Drug-Loaded Thermosensitive Hydrogels

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Saeednia, L. Usta, A. Asmatulu, R.
Copyright Year	2013
Abstract	Hydrogels are the promising classes of polymeric drug delivery systems with the controlled release rates. Among them, injectable thermosensitive hydrogels with transition temperature around the body temperature have been wildly considered. Chitosan is one of the most abundant natural polymers, and its biocompatibility and biodegradability makes it a favorable thermosensitive hydrogel that has been attracted much attention in biomedical field worldwide. In this work, a thermosensitive and injectable hydrogel was prepared using chitosan and β-glycerophosphate (β-GP) incorporated with an antibacterial drug (gentamycin). This drug loaded hydrogel is liquid at room temperature, and becomes more solidified gel when heated to the body temperature. Adding β-GP into chitosan and drug molecules and heating the overall solution makes the whole homogenous liquid into gel through a 3D network formation. The gelation time was found to be a function of temperature and concentration of β-GP. This thermosensitive chitosan based hydrogel system was characterized using FTIR and visual observation to determine the chemical structure and morphology. The results confirmed that chitosan/(β-GP) hydrogels could be a promising controlled-release drug delivery system for many deadly diseases.
File Format	PDF
ISBN	9780791856222
DOI	10.1115/IMECE2013-66489
Volume Number	Volume 3B: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2013 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2013-11-15
Publisher Place	San Diego, California, USA
Access Restriction	Subscribed
Subject Keyword	Drug Drug release Chitosan Hydrogel Β-glycerophosphate Thermosensitivity Drugs Hydrogels
Content Type	Text
Resource Type	Article

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