NDLI: Structural Performance Analysis of Hydroxyapatite Scaffolds for Tissue Engineering

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Gallegos-Nieto, Enrique Medellín-Castillo, Hugo I. Dirk, F. De Lange Mejía-Rodríguez, Gilberto
Copyright Year	2013
Abstract	The development of hydroxyapatite (HA) scaffolds for tissue regeneration, particularly for bone regeneration, is an alternative to treat bone defects due to cancer, other diseases or trauma. Although the hydroxyapatite has been widely studied in the literature, there are still some disparities regarding its mechanical performance. This paper presents the analysis of the structural performance of hydroxyapatite scaffolds based on experimental tests and numerical simulations. HA scaffolds with variable porosity were fabricated by the water soluble polymer method, using the Poly Vinyl Alcohol (PVA) as pore former. These scaffolds were then characterized by scanning electronic microscopy (SEM), stereo microscope and X ray diffraction (XRD). Different porous structures models were considered and analyzed by the finite element method (FEM). Compressive tests were carried out and used to validate the proposed numerical models. Also a theoretical analysis based on the Gibson and Ashby [1] model was performed. Finally the experimental, numerical and theoretical results were compared and the results show that the proposed numerical and theoretical models can be used to predict, with adequate accuracy, the mechanical behavior of HA scaffolds for different porosity values.
File Format	PDF
ISBN	9780791856222
DOI	10.1115/IMECE2013-65580
Volume Number	Volume 3B: Biomedical and Biotechnology Engineering
Conference Proceedings	ASME 2013 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2013-11-15
Publisher Place	San Diego, California, USA
Access Restriction	Subscribed
Subject Keyword	Hydroxyapatite (ha) Porosity Scaffolds Tissue engineering Equipment performance Tissue scaffolds Mechanical behavior Water-soluble polymers Computer simulation Ethanol X-ray diffraction Theoretical analysis Finite element methods Diseases Microscopy Bone Microscopes Cancer
Content Type	Text
Resource Type	Article

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