NDLI: A Thermoresponsive Hydrogel Based Controlled Drug Delivery Device

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Blanco, Letia Panos, S. Shiakolas Pranesh, B. Aswath Christopher, B. Alberts Grace, Chris Godfrey, Kyle Patin, Drew
Copyright Year	2012
Abstract	Thermoresponsive hydrogels exhibit the unique property of volume change as a function of change in temperature as they transition between hydrophilic and hydrophobic states. These hydrogels can be loaded with drug/protein and serve as reservoirs for drug/protein delivery applications. A hydrogel based device for controlled drug delivery is designed with a number of subsystems that are interfaced with LabVIEW for development of a functional device. The device was designed using analytical and finite element analysis procedures and fabricated. In this manuscript, the device design will be reviewed and discussed. A parametric study was performed to examine the device operation and performance as function of hydrogel heating/cooling temperature profiles. Subsequently, the device was employed in a series of experiments to examine the delivery of a protein as a function of thermal stimuli. The matrix used in this study was poly(ethylene glycol) diacrylate (PEGDA) and the drug delivery nanoparticles carriers were poly(N-isopropylacrylamide-co-acrylamide (PNIPAM) with a lower critical solution temperature (LCST) around 40°C. The protein of choice was bovine serum albumin (BSA). The results of this study illustrate that the development of a multi-drug or therapeutic delivery device is possible and that individual drugs can be delivered on demand using a closed loop control system.
Starting Page	371
Ending Page	378
Page Count	8
File Format	PDF
ISBN	9780791845189
DOI	10.1115/IMECE2012-88564
Volume Number	Volume 2: Biomedical and Biotechnology
Conference Proceedings	ASME 2012 International Mechanical Engineering Congress and Exposition
Language	English
Publisher Date	2012-11-09
Publisher Place	Houston, Texas, USA
Access Restriction	Subscribed
Subject Keyword	Drugs Drug delivery systems Temperature Cooling Hydrogels Control systems Temperature profiles Proteins Design Nanoparticles Heating Reservoirs Finite element analysis
Content Type	Text
Resource Type	Article

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