NDLI: Nanowire-GMR Integrated Microfluidic Biosensor

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Bellamkonda, Ramya John, Tom Mathew, Bobby Hegab, Hisham Decoster, Mark Davis, Despina
Copyright Year	2009
Abstract	Nanowires based GMR is ideal to be integrated in microfluidic devices due to its efficient detection of sensitive magnetic fields. Nanowire based GMR microfluidic sensor is used to detect different fluids based on their magnetic behavior. This paper demonstrates the fabrication and testing of nanowire based GMR biosensors with four different control solutions: 1) DI-water, 2) Phosphate Buffered Saline (PBS), 3) polystyrene superparamagnetic beads, and 4) commercially available magnetic Dynabeads. The device is fabricated in PDMS by using a lithographically patterned silicon wafer as the mold. The nanowire based GMR material, 3 mm by 3 mm in size, is inserted inside the PDMS close to the channel during the fabrication. The channel in the PDMS substrate is sealed by bonding it to a glass plate using Reactive-Ion-Exchanger (RIE). GMR device is tested potentiostatically using a computer controlled function generator (Solatron, SI 1287). A highest resistance of 0.748 Ω. is recorded for the sensor, in the absence of magnetic field. A resistance change of 0.6% is obtained in the presence of a magnetic field (B = 0.035T) between water and polystyrene superparamagnetic beads when pumped through the microchannel. The sensor showed a resistance difference of 0.31% between 1X diluted PBS and 100X diluted dynabeads, in the presence of a constant magnetic field of 0.035T. This characterization would be useful in the development of a BioMEMS sensor using nanowire based GMR.
Sponsorship	Fluids Engineering Division
Starting Page	535
Ending Page	538
Page Count	4
File Format	PDF
ISBN	9780791843734
DOI	10.1115/FEDSM2009-78529
e-ISBN	9780791838556
Volume Number	Volume 2: Fora
Conference Proceedings	ASME 2009 Fluids Engineering Division Summer Meeting
Language	English
Publisher Date	2009-08-02
Publisher Place	Vail, Colorado, USA
Access Restriction	Subscribed
Subject Keyword	Water Computers Reactive-ion etching Plasma desorption mass spectrometry Glass Superparamagnetism Generators Semiconductor wafers Microchannels Fluids Biomedical microelectromechanical systems Nanowires Sensors Manufacturing Biosensors Magnetic fields Bonding Microfluidics Testing
Content Type	Text
Resource Type	Article

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