NDLI: Effects of Geometric Hystersis in Lung Deformation on Irreversibility in Trajectories of Fine Inhaled Particles

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Zendehbad, Mohsen Mohammad, S. Saidi Sani, Mahdi
Copyright Year	2010
Abstract	In order to perform the drug delivery via lung, tracking the trajectories of fine inhaled particles in the acinar airways is of high importance. The causes of irreversibility in the motion of fine particles (0.1–1 micron) and chaotic flow deep in the acinar region of lung has been always under investigation. In this study we demonstrate the importance of geometric hystersis and asynchrony of lung deformation on the issue. We adapted a 2D axisymmetric geometry of alveolated duct from recent relative works and deformed it in a way that some hystersis would appear in a respiration period. The overall deformation of duct was corresponding to the transpulmonary pressure of lung reported in physiological books and the Re number was matched with the actual flow in acinar airways. The geometric hystersis had the same amount as the measured hystersis in rat lungs available in relative literature. We performed a lagrangian particle tracking for different cases with and without geometric hystersis. Results confirm that as soon as some asynchrony appears in wall motion the trajectories of particles become extremely irreversible and hence we propose that the geometric hystersis can be a principal reason for observed irreversibility in acinar airways.
Sponsorship	International
Starting Page	789
Ending Page	796
Page Count	8
File Format	PDF
ISBN	9780791849156
DOI	10.1115/ESDA2010-25116
e-ISBN	9780791838778
Volume Number	ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, Volume 1
Conference Proceedings	ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis
Language	English
Publisher Date	2010-07-12
Publisher Place	Istanbul, Turkey
Access Restriction	Subscribed
Subject Keyword	Human lung Geometric hystersis Drug delivery Respiration modeling Kinematic irreversibility Drug delivery systems Deformation Lung Particulate matter
Content Type	Text
Resource Type	Article

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