NDLI: Numerical Simulation of the Hemodynamics in 6 mm and 6–8 mm Hemodialysis Grafts and Investigation of Biomechanical Consequences

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Sarmast, Mohammad Oscuii, Hanieh Niroomand Ghalichi, Farzan Samiei, Ehsan
Copyright Year	2010
Abstract	Hemodialysis vascular access dysfunction is still considered as a major cause of morbidity and mortality in hemodialysis patients. The most common cause of this vascular access dysfunction is venous stenosis secondary to the progression of venous intimal hyperplasia at the graft-vein junction or in the draining vein. The geometry of the vessels and the local hemodynamics are believed to be contributory factors in the development of intimal hyperplasia. In the present study, the hemodynamic parameters in two types of vascular access grafts of different diameters: 6 mm and 8 mm tapered to 6 mm at the arterial site were compared. A three-dimensional CFD model was developed to simulate blood flow in the two graft types. The boundary conditions applied were a pulsatile velocity waveform at the arterial inlet and a pulsatile pressure waveform at the venous outlet. Computational fluid dynamics software was used to solve the time dependent Navier-Stokes equations under physiological conditions in both graft types. Since the cross section area and the diameter of the venous side of the tapered graft are larger than those of the straight one, the flow aligns well with the vein downstream of the graft and hence the smaller vortices are generated. Comparing the parameters at the two venous anastomosis regions also indicates that in spite of the higher flow rate in 6–8 mm tapered graft, the velocity and the wall shear stress values are lower than the values of the 6 mm straight graft.
Sponsorship	International
Starting Page	779
Ending Page	788
Page Count	10
File Format	PDF
ISBN	9780791849156
DOI	10.1115/ESDA2010-24804
e-ISBN	9780791838778
Volume Number	ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis, Volume 1
Conference Proceedings	ASME 2010 10th Biennial Conference on Engineering Systems Design and Analysis
Language	English
Publisher Date	2010-07-12
Publisher Place	Istanbul, Turkey
Access Restriction	Subscribed
Subject Keyword	Navier-stokes equations Computer simulation Computational fluid dynamics Hemodialysis Computer software Vessels Flow (dynamics) Pressure Blood flow Biomechanics Drainage Geometry Vortices Shear stress Boundary-value problems Physiology Hemodynamics Junctions
Content Type	Text
Resource Type	Article

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