NDLI: Freezing-Induced Fluid-Matrix Interaction in Poroelastic Material

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Han, Bumsoo Miller, Jeffrey D. Jung, Jun K.
Copyright Year	2009
Abstract	Freezing of biological tissue is emerging in various biomedical applications. The success of these applications requires precise control of the tissue functionality, which is closely associated with the microstructure of the extracellular matrix (ECM). In the present study, the spatiotemporal effects of freezing on the ECM were experimentally and theoretically investigated by approximating biological tissue as a poroelastic material saturated with interstitial fluid. The experiments with type I collagen gel showed that its matrix underwent two distinct levels of structural changes due to freezing: enlarged pore structure of the matrix and increased collagen fibril diameters. The extent of these changes was augmented as the freezing temperature was lowered. The theoretical model suggested that the interstitial fluid might be transported toward the unfrozen region from the phase change interface due to the volumetric expansion associated with the water-ice phase change, and the transported fluid could interact with the matrix and enlarge its pore structure. The model also illustrated the effects of matrix structural properties on this interaction including initial porosity, hydraulic conductivity, and elastic modulus. These results imply that an identical macroscopic freezing protocol may result in different microstructural alterations of poroelastic materials depending on the structural properties of the matrix. This may be relevant to understanding the tissue-type dependent outcomes of cryomedicine applications and be useful in designing cryomedicine applications for a wide variety of tissues.
Starting Page	021002
Ending Page	021008
Page Count	7
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	131
Issue Number	2
DOI	10.1115/1.3005170
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2008-12-09
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biological tissues Fluids Freezing Porosity Water
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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