NDLI: Scaffolds for Engineering Smooth Muscle Under Cyclic Mechanical Strain Conditions

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Byung-Soo Kim Mooney, David J.
Copyright Year	2000
Abstract	Cyclic mechanical strain has been demonstrated to enhance the development and function of engineered smooth muscle (SM) tissues, but appropriate scaffolds for engineering tissues under conditions of cyclic strain are currently lacking. These scaffolds must display elastic behavior, and be capable of inducing an appropriate smooth muscle cell (SMC) phenotype in response to mechanical signals. In this study, we have characterized several scaffold types commonly utilized in tissue engineering applications in order to select scaffolds that exhibit elastic properties under appropriate cyclic strain conditions. The ability of the scaffolds to promote an appropriate SMC phenotype in engineered SM tissues under cyclic strain conditions was subsequently analyzed. Poly(L-lactic acid)-bonded polyglycolide fiber-based scaffolds and type I collagen sponges exhibited partially elastic mechanical properties under cyclic strain conditions, although the synthetic polymer scaffolds demonstrated significant permanent deformation after extended times of cyclic strain application. SM tissues engineered with type I collagen sponges subjected to cyclic strain were found to contain more elastin than control tissues, and the SMCs in these tissues exhibited a contractile phenotype. In contrast, SMCs in control tissues exhibited a structure more consistent with the nondifferentiated, synthetic phenotype. These studies indicate the appropriate choice of a scaffold for engineering tissues in a mechanically dynamic environment is dependent on the time frame of the mechanical stimulation, and elastic scaffolds allow for mechanically directed control of cell phenotype in engineered tissues. [S0148-0731(00)00103-5]
Starting Page	210
Ending Page	215
Page Count	6
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	122
Issue Number	3
DOI	10.1115/1.429651
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2000-02-06
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Biological tissues Deformation Elasticity Fibers Mechanical properties Muscle Particle filtering (numerical methods) Polymers Sheet molding compound (Plastics) Signals Sliding mode control Structural frames Surface mount components Tissue engineering
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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