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| Content Provider | African Journals Online (AJOL) |
|---|---|
| Author | Nicolas Kalulu Taba Paulin Mbaya Jean Jacques Tamfum Muyembe Octavie Metila Lunguya Jean Marie Ntumba Kayembe Steve Mundeke Ahuka Hippolyte Nani Tuma Situakibanza Serge Fueza Bisuta Marie José Bajani Kabedi |
| Abstract | Context and objective : In endemic regions such as the Democratic Republic of the Congo, children are likely to be exposed to tuberculosis (TB) through close contact. Failure to diagnose can have devastating consequences. The objective of the present study was to determine the frequency of TB and the primary resistance of Mycobacterium tuberculosis strains to antituberculosis drugs as well as genetic variants. Methods. The study is cross-sectional and descriptive carried out between June 2011 and December 2017 in Kinshasa among children presumed to have TB. Were included, children with the suggestive signs of TB appearing in the age group of 0-14 years. Samples were examined by Ziehl-Neelsen and cultured on Löwenstein-Jensens medium. The strains were tested for anti-tuberculosis drugs by the technique of proportions and typed by the technique of spoligotyping. The difference in frequency distribution was carried out by the chi-square test. Results. Forty-eight strains of M. tuberculosis (15.4 %) out of 312 cultures launched were isolated. Ten strains (20.8 %) out of 48 isolated were resistant to at least one antituberculosis drug, most frequently isoniazid (INH). Among the isolated strains, 2 (4.2%) were resistant to rifampicin including 1 MR-TB and 1 preXDR strain. Two genotypic strains were observed, namely, LAM (66, 7%) and Haarlem (33, 3%). Conclusion. Active search confirms that childhood TB is relatively common and resistant to at least one anti-tuberculosis drug (especially INH) Contexte et objectif. Dans les régions endémiques y compris la République Démocratique du Congo, les enfants sont susceptibles d’être exposés à la tuberculose (TB) par un contact dans l’entourage. L’absence de diagnostic peut avoir des conséquences dévastatrices. L’objectif de la présente étude était de déterminer la fréquence de TB, la résistance primaire des souches de Mycobacterium tuberculosis aux antituberculeux ainsi que des variants génétiques. Méthodes. Cette étude transversale et descriptive a été réalisée, entre juin 2011 et décembre 2017, à Kinshasa chez les enfants présumés TB. Les enfants ayant les signes évocateurs de TB figurant dans la tranche d’âge de 0-14 ans étaient inclus. Les échantillons ont été examinés par le Ziehl et mis en culture sur le milieu de Löwenstein-Jensens. Les souches étaient testées aux antituberculeux par la technique des proportions et typées par Spoligotyping. La comparaison des proportions a été faite à l’aide du test de chi-carré de Pearson. Résultats. Quarante-huit souches de Mycobacterium tuberculosis (15,4 %) ont été isolées. Dix souches (20,8%) étaient résistantes à au moins un antituberculeux plus fréquemment à l’INH. Le génotype LAM (66,7 %) et Haarlem (33,3%) était observé. Conclusion. La recherche active de TB infantile confirme qu’elle est relativement fréquente et est résistante à au moins un antituberculeux (surtout à l’INH). |
| Ending Page | 5381 |
| Starting Page | 5375 |
| File Format | |
| ISSN | 23095784 |
| e-ISSN | 23133589 |
| DOI | 10.4314/aamed.v16i4.10 |
| Journal | Annales Africaines de Medecine |
| Issue Number | 4 |
| Volume Number | 16 |
| Language | English French |
| Publisher Date | 2023-09-28 |
| Access Restriction | Open |
| Subject Keyword | Health |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
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