NDLI: Alanine Aminotransferase and Aspertate Aminotransaminase Activities in Wistar Rats Fed with Musa paradisiaca (Plantain) Stem Pulp in Aluminium Chloride Induced Hepatic Oxidative Stress

Alanine Aminotransferase and Aspertate Aminotransaminase Activities in Wistar Rats Fed with Musa paradisiaca (Plantain) Stem Pulp in Aluminium Chloride Induced Hepatic Oxidative Stress

Content Provider African Journals Online (AJOL)
Author E. D. Kpomah E. M. Arhoghro
Abstract In this study, the effect of Musa paradisiaca (plantain) stem pulp on aluminium chloride (AlCl3) induced hepatotoxicity was studied. Fifteen (15) healthy female wistar rats after acclimatization for two weeks were randomly distributed to three (3) groups, with five (5) rats in each group. Group 1 served as control and received as control pelletized growers feed and distilled water throughout the experiment (14 days). Group 2 received 100mg/kg/body weight (b.w.) of aluminium chloride and was fed with pelletized growers feed and distilled water for 14 days and group 3 received 100mg/kgb.w of aluminium chloride and 2mL/kg of the juice gotten from M. paradisiaca and were also allowed free access to feed and water ad libitum for 14 days. Blood samples were collected via cardiac puncture and analyzed for AST, ALT, MDA and SOD. Results revealed that there was a significant increase in AST and ALT levels respectively from 67.83±1.39 to 173.40±0.81 and 43.73±1.00 to 128.24±0.68 after treatment with AlCl3 compared to control while administration of M. paradisiaca extract ameliorated the adverse effects of AlCl3 when compared to AlCl3 treated groups from 173.40±0.81 to 72.40±1.71 and 128.24±0.68 to 45.83±1.22 respectively. There was a significant decrease (P<0.05) in SOD level from 6.04± 0.49 to 2.56±0.86 of AlCl3 compared to control and a significant increase (P<0.05) from 2.56±0.86 to 6.00±1. 56 in SOD level was observed in M. paradisiaca treated groups when compared to AlCl3 treated group. It was also observed that there was a significant (P<0.05) from 401.09±0.10 to 1207.98±1.39 in MDA level after treatment with AlCl3 compared to control while there was a significant decrease (P<0.05) from 1207.98±1.39 to 388.83±31.15 in MDA level of M. paradisiaca treated groups when compared to the AlCl3 treated groups. It was observed that M. paradisiaca showed a mitigating effect on aluminium chloride-induced hepatotoxicity and thus justifying the hepatoprotective property of M. paradisiaca.
Ending Page 1062
Starting Page 1057
File Format PDF
ISSN 11198362
e-ISSN 26591502
DOI 10.4314/jasem.v26i6.9
Journal Journal of Applied Sciences and Environmental Management
Issue Number 6
Volume Number 26
Language English
Publisher Date 2022-06-24
Access Restriction Open
Subject Keyword General Science Aluminium chloride antioxidant oxidative stress hepatoprotective Musa paradisiac
Content Type Text
Resource Type Article
Subject Decision Sciences

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Alanine Aminotransferase and Aspertate Aminotransaminase Activities in Wistar Rats Fed with Musa paradisiaca (Plantain) Stem Pulp in Aluminium Chloride Induced Hepatic Oxidative Stress

Content Provider	African Journals Online (AJOL)
Author	E. D. Kpomah E. M. Arhoghro
Abstract	In this study, the effect of Musa paradisiaca (plantain) stem pulp on aluminium chloride (AlCl3) induced hepatotoxicity was studied. Fifteen (15) healthy female wistar rats after acclimatization for two weeks were randomly distributed to three (3) groups, with five (5) rats in each group. Group 1 served as control and received as control pelletized growers feed and distilled water throughout the experiment (14 days). Group 2 received 100mg/kg/body weight (b.w.) of aluminium chloride and was fed with pelletized growers feed and distilled water for 14 days and group 3 received 100mg/kgb.w of aluminium chloride and 2mL/kg of the juice gotten from M. paradisiaca and were also allowed free access to feed and water ad libitum for 14 days. Blood samples were collected via cardiac puncture and analyzed for AST, ALT, MDA and SOD. Results revealed that there was a significant increase in AST and ALT levels respectively from 67.83±1.39 to 173.40±0.81 and 43.73±1.00 to 128.24±0.68 after treatment with AlCl3 compared to control while administration of M. paradisiaca extract ameliorated the adverse effects of AlCl3 when compared to AlCl3 treated groups from 173.40±0.81 to 72.40±1.71 and 128.24±0.68 to 45.83±1.22 respectively. There was a significant decrease (P<0.05) in SOD level from 6.04± 0.49 to 2.56±0.86 of AlCl3 compared to control and a significant increase (P<0.05) from 2.56±0.86 to 6.00±1. 56 in SOD level was observed in M. paradisiaca treated groups when compared to AlCl3 treated group. It was also observed that there was a significant (P<0.05) from 401.09±0.10 to 1207.98±1.39 in MDA level after treatment with AlCl3 compared to control while there was a significant decrease (P<0.05) from 1207.98±1.39 to 388.83±31.15 in MDA level of M. paradisiaca treated groups when compared to the AlCl3 treated groups. It was observed that M. paradisiaca showed a mitigating effect on aluminium chloride-induced hepatotoxicity and thus justifying the hepatoprotective property of M. paradisiaca.
Ending Page	1062
Starting Page	1057
File Format	PDF
ISSN	11198362
e-ISSN	26591502
DOI	10.4314/jasem.v26i6.9
Journal	Journal of Applied Sciences and Environmental Management
Issue Number	6
Volume Number	26
Language	English
Publisher Date	2022-06-24
Access Restriction	Open
Subject Keyword	General Science Aluminium chloride antioxidant oxidative stress hepatoprotective Musa paradisiac
Content Type	Text
Resource Type	Article
Subject	Decision Sciences

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