Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats.

Content Provider	Europe PMC
Author	Eleazu, Chinedum O. Okafor, Polycarp
Copyright Year	2015
Description	Aim This study aims to investigate the effect of unripe plantain (Musa paradisiaca) on markers of hepatic dysfunction in streptozotocin induced diabetic rats. Methods Blood glucose; relative liver weight (RLW); relative kidney weight (RKW); relative heart weight (RHW); relative pancreatic weight (RPW); serum and hepatic serum aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP); serum amylase, lipase, total, and conjugated bilirubin; and chemical analysis of the test feed were determined using standard techniques. Results The diabetic rats had significant alteration (P < 0.05) of blood glucose; RLW; RKW; RPW; serum and hepatic AST, ALT, and ALP; serum total and conjugated bilirubin; and serum lipase activities compared with nondiabetic while these parameters were significantly improved (P < 0.05) in the rats fed unripe plantain. There were no significant differences (P > 0.05) in the RHW of the rats in the three groups, as well as significant decreases (P < 0.05) in the amylase levels of the diabetic rats compared with the nondiabetic, but there was nonsignificant increase (P > 0.05) in the amylase levels of the rats fed unripe plantain compared with the nondiabetic rats. The test and standard rat feeds contained considerable amount of proteins, carbohydrates, fats, phenols, and crude fiber. Conclusion Amelioration of acute pancreatitis by unripe plantain could play a key role in its management of diabetes and related complications.
Abstract	Aim This study aims to investigate the effect of unripe plantain (Musaparadisiaca) on markers of hepatic dysfunction instreptozotocin induced diabetic rats. Methods Blood glucose; relative liver weight (RLW); relative kidney weight (RKW);relative heart weight (RHW); relative pancreatic weight (RPW); serum andhepatic serum aspartate transaminase (AST), alanine transaminase (ALT), andalkaline phosphatase (ALP); serum amylase, lipase, total, and conjugatedbilirubin; and chemical analysis of the test feed were determined usingstandard techniques. Results The diabetic rats had significant alteration (P < 0.05)of blood glucose; RLW; RKW; RPW; serum and hepatic AST, ALT, and ALP; serumtotal and conjugated bilirubin; and serum lipase activities compared withnondiabetic while these parameters were significantly improved(P < 0.05) in the rats fed unripe plantain. Therewere no significant differences (P > 0.05) in the RHW ofthe rats in the three groups, as well as significant decreases(P < 0.05) in the amylase levels of the diabeticrats compared with the nondiabetic, but there was nonsignificant increase(P > 0.05) in the amylase levels of the rats fedunripe plantain compared with the nondiabetic rats. The test and standardrat feeds contained considerable amount of proteins, carbohydrates, fats,phenols, and crude fiber. Conclusion Amelioration of acute pancreatitis by unripe plantain could play a key rolein its management of diabetes and related complications.
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ISSN	20611617
Volume Number	7
PubMed Central reference number	PMC4369141
Issue Number	1
PubMed reference number	25838921
Journal	Interventional Medicine & Applied Science [Interv Med Appl Sci]
e-ISSN	20615094
DOI	10.1556/imas.7.2015.1.2
Language	English
Publisher	Akadémiai Kiadó
Publisher Date	2015-03-20
Access Restriction	Open
Rights License	Copyright © 2015, Akadémiai Kiadó,Budapest
Subject Keyword	diabetes streptozotocin unripe plantain
Content Type	Text
Resource Type	Article
Subject	Medicine