NDLI: Early detection of critical pulmonary shunts in infants

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Early detection of critical pulmonary shunts in infants

Content Provider	ACM Digital Library
Author	Weimer, James Ivanov, Radoslav Lee, Insup Rehman, Mohamed Simpao, Allan
Abstract	This paper aims to improve the design of modern Medical Cyber Physical Systems through the addition of supplemental noninvasive monitors. Specifically, we focus on monitoring the arterial blood oxygen content $(C_{a}O_{2}),$ one of the most closely observed vital signs in operating rooms, currently measured by a proxy -- peripheral hemoglobin oxygen saturation $(S_{p}O_{2}).$ While $S_{p}O_{2}$ is a good estimate of $O_{2}$ content in the finger where it is measured, it is a delayed measure of its content in the arteries. In addition, it does not incorporate system dynamics and is a poor predictor of future $C_{a}O_{2}$ values. Therefore, as a first step towards supplementing the usage of $S_{p}O_{2},$ this work introduces a predictive monitor designed to provide early detection of critical drops in $C_{a}O_{2}$ caused by a pulmonary shunt in infants. To this end, we develop a formal model of the circulation of oxygen and carbon dioxide in the body, characterized by unknown patient-unique parameters. Employing the model, we design a matched subspace detector to provide a near constant false alarm rate invariant to these parameters and modeling uncertainties. Finally, we validate our approach on real-patient data from lung lobectomy surgeries performed at the Children's Hospital of Philadelphia. Given 198 infants, the detector predicted 81% of the critical drops in $C_{a}O_{2}$ at an average of about 65 seconds earlier than the $S_{p}O_{2}-based$ monitor, while achieving a 0.9% false alarm rate (representing about 2 false alarms per hour).
Starting Page	110
Ending Page	119
Page Count	10
File Format	PDF
ISBN	9781450334556
DOI	10.1145/2735960.2735962
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-04-14
Publisher Place	New York
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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