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| Content Provider | ACM Digital Library |
|---|---|
| Author | Marshall, M. Scott Prud'hommeaux, Eric McCusker, Jim Malone, James Miller, Michael Serra, Philippe Rocca Zhao, Jun Das, Sudeshna Fox, Ronan Deus, Helena F. Adamusiak, Tomasz |
| Abstract | Sharing and describing experimental results unambiguously with sufficient detail to enable replication of results is a fundamental tenet of scientific research. In today's cluttered world of "-omics" sciences, data standards and standardized use of terminologies and ontologies for biomedical informatics play an important role in reporting high-throughput experiment results in formats that can be interpreted by both researchers and analytical tools. Increasing adoption of Semantic Web and Linked Data technologies for the integration of heterogeneous and distributed Health Care and Life Sciences (HCLS) datasets has made the reuse of standards even more pressing; dynamic semantic query federation can be used for integrative bioinformatics when ontologies and identifiers are reused across data instances. We present here a methodology to integrate the results and experimental context of three different representations of microarray-based transcriptomic experiments: the Gene Expression Atlas, the W3C BioRDF task force approach to reporting provenance of microarray experiments, and the HSCI blood genomics project. Our approach does not attempt to improve the expressivity of existing standards for genomics but, instead, to enable integration of existing datasets published from microarray-based transcriptomic experiments. SPARQL Construct is used to create a posteriori mappings of concepts and properties and linking rules that match entities based on query constraints. We discuss how our integrative approach can encourage reuse of the Experimental Factor Ontology (EFO) and the Ontology for Biomedical Investigations (OBI) for the reporting of experimental context and results of gene expression studies. A demo is made available at http://ui.genexpressfusion.googlecode.com/hg/index.html. |
| Starting Page | 6 |
| Ending Page | 7 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781450310765 |
| DOI | 10.1145/2166896.2166900 |
| Language | English |
| Publisher | Association for Computing Machinery (ACM) |
| Publisher Date | 2011-12-07 |
| Publisher Place | New York |
| Access Restriction | Subscribed |
| Subject Keyword | Sparql Linked data Genomics Life sciences |
| Content Type | Text |
| Resource Type | Article |
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