NDLI: Human immunodeficiency virus (HIV) proteomics resource at BioAfrica

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Human immunodeficiency virus (HIV) proteomics resource at BioAfrica

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Human immunodeficiency virus (HIV) proteomics resource at BioAfrica

Content Provider	ACM Digital Library
Author	Masson, Patrick Hulo, Chantal Sommer, Paula Druce, Megan de Oliveira, Tulio Le Mercier, Philippe
Abstract	The Human Immunodeficiency Virus (HIV) is the cause of AIDS, one of the Worlds' deadliest infections, with approximately 34 million people currently infected with HIV. As a result, numerous HIV research has been carried out in the past 30 years, producing a large number of publications. This has highlighted the need for comprehensive, accurate and well-annotated HIV resources that allow for easy access to reliable information that is normally difficult to find. Furthermore, with the increase in antiviral drug resistance there is an ever-growing necessity for the development of novel antiviral therapies. Considering that the current antiviral drugs target specific HIV proteins, extensive knowledge of these proteins is required by researchers. The BioAfrica HIV proteomics resource was developed in 2005 to provide users with the latest information on HIV-1 $proteins^{1}.$ This included information on protein structure, post-translational and transcriptional modifications, gene expression, protein function, and protein-protein interactions; as well as to provide links to relevant bioinformatics tools. This resource has been very popular over the years and has been referenced in UniProt. In a joint-collaboration between Africa Centre and the Swiss Institute of Bioinformatics (SIB), the BioAfrica HIV proteomics resource has been updated to include current knowledge on HIV protein research. Furthermore, additional features to the resource have been added; including information on HIV-1/human protein-protein interactions, genomic location and sequence information, HIV anti-retrovirals and drug resistance mutations, as well as links to relevant HIV databases. In addition, this proteomics resource has been linked to a comprehensive and well-annotated HIV resource that has curated knowledge on aspects of the HIV life cycle. This HIV resource is housed in ViralZone (http://viralzone.expasy.org/all_by_species/4976.html) and was created as part of the same Swiss-South Africa collaboration. The BioAfrica HIV proteomics resource is publically accessible via the BioAfrica website (http://bioafrica.net/proteomics/HIVproteome.html).
Starting Page	497
Ending Page	498
Page Count	2
File Format	PDF
ISBN	9781450338530
DOI	10.1145/2808719.2811426
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-09-09
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Hiv Viralzone Proteomics Biocuration Bioinformatics Bioafrica
Content Type	Text
Resource Type	Article

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