NDLI: Bone disease prediction and phenotype discovery using feature representation over electronic health records

Please wait, while we are loading the content...

Discovering de facto diagnosis specialties

Updating channel adjacent amino acids for a flexible protein molecule

Towards the assessment of GRN algorithms based on (disease) ontology

Introduction to the workshop on computational health science

Scalable multipartite subgraph enumeration for integrative analysis of heterogeneous experimental functional genomics data

An experimental design to reduce dynamics uncertainty in genomic networks

Multi-core dynamic parallelism for multiple sequence alignment and counting metrics

Building and implementing data science products to change healthcare IT

A web tool for measuring gene semantic similarities by combining gene ontology and gene co-function networks

High-speed westfall-young permutation procedure for genome-wide association studies

Intelligent F-information for genetic swarm algorithm based fuzzy expert system

Efficient learning of association rules from human phenotype ontology

How do Twitter, Wikipedia, and Harrison's principles of medicine describe heart attacks?

A multi-agent system with reinforcement learning agents for biomedical text mining

Computing interaction probabilities in signaling networks

Selection of genes using long-term influence and sensitivity analysis

Senior health management through internet of things and real-time big data analytics

Two methods for constructing a gene ontology-based feature network for a Bayesian network classifier and applications to datasets of aging-related genes

Spatiotemporal visualization of cell membrane dynamics and protein colocalization reveals correlation between membrane dynamics and metastatic invasion

A fast and accurate parallel algorithm for genome mapping assembly aimed at massively parallel sequencers

A method for analyzing health behavior in online forums

Identifying molecular complexes in biological networks through context sensitive network querying

A generalized lattice model for clustering metagenomic sequences

A bayesian nonparametric approach for latent class regression analysis

Two-dimensional model of bipolar PopZ polymerization in caulobacter crescentus

Bingocize® 3.0: a game based platform for promoting wellness in older adults

Toward an analytical framework for proteomics software

How TV advertising and social network help tobacco control campaigns influence more

Computational identification of key functional genes associated with fusarium verticillioides pathogenicity

Learning causal structures with background knowledge in health data

Mining k-median chromosome association graphs from a population of heterogeneous cells

Improving MiRNA prediction accuracy by deep learning strategies

Voice signal features analysis and classification: looking for new diseases related parameters

A computational framework for finding functional modules across multiple biological networks

Big data and predictive modeling topics in healthcare

REFECT: a novel paradigm for correcting short reads

Poster abstract: RNA thermodynamic conformational entropy

An alignment-free approach to cluster proteins using frequency of conserved k-mers

Optimal bayesian feature filtering

Domain specific information retrieval and text mining in medical document

Methylome meets maternity ward: predicting pre-eclampsia in early pregnancy

A computationally efficient solution strategy for optimal gene knockouts for targeted overproduction

Portable neurological disease assessment using temporal analysis of speech

Detection of a fusion gene using soft-clipping reads in exome-sequencing data

Inference of protein-protein interaction networks from multiple heterogeneous data

Estimating reachability in dense biological networks

The systems toxicology challenge: how to leverage omics data to predict mechanisms of toxicity?

A mobile sensor system for gait analysis supporting the assessment of rehabilitation measures

Computational support system for personalized medicine

The potential power of dynamics in epistasis analysis

Fair evaluation of global network aligners

Counting motifs in probabilistic biological networks

Super deduper, fast PCR duplicate detection in fastq files

Efficient data reduction for large-scale genetic mapping

A less biased analysis of metalloproteins' coordination geometries

MICA: MicroRNA integration for active module discovery

Analogy-based entropic similarity between observations and/or predictions (AESOP): an entropically weighted information-theoretic measure for benchmarking computational accuracy

Integrated querying of disparate association and interaction data in biomedical applications

Human immunodeficiency virus (HIV) proteomics resource at BioAfrica

EpiCaster: an integrated web application for situation assessment and forecasting of global epidemics

PlasMatch: a tool for choosing usable restriction enzymes and plasmid backbones

Bermuda: de novo assembly of transcripts with new insights for handling uneven coverage

Structural diversity measures for RNA

Multiple reference networks improve accuracy of signaling network construction

A new method for DNA sequencing error verification and correction via an on-disk index tree

Discrimination of recurrent CNVs from individual ones from multisample aCGH by jointly constrained minimization

Unsupervised identification of redundant domain entries in InterPro database using clustering techniques

Rapid, separable compression enables fast analyses of sequence alignments

Pairwise structure alignment specifically tuned for surface pockets and interaction interfaces

Cloud-assisted distributed private data sharing

Clinical knowledgebase to interprete genomic variations from targeted exome sequencing of patient tumor samples

Bone disease prediction and phenotype discovery using feature representation over electronic health records

The DOE systems biology knowledgebase (KBase): progress towards a system for collaborative and reproducible inference and modeling of biological function

Accelerated molecular mechanical and solvation energetics on multicore CPUs and manycore GPUs

A robotics approach to analysis of non-isotropic random walks

Identification of significant genetic variants via SLOPE, and its extension to group SLOPE

HPC-BLAST: distributed BLAST for xeon phi clusters

Unified tests for fine scale mapping and identifying sparse high-dimensional sequence associations

Boolean network modeling for systematic identification of anticancer drug resistance in colorectal cancer

Particle swarm optimization for radiation therapy planning

Efficient computation of distance incorporated codon autocorrelation (DICA) score using fast Fourier transform

Convolutional neural networks for biomedical text classification: application in indexing biomedical articles

A logical exposition of dirac 3-polarizer experiment and its potential impact on computational biology

Improving biological significance of gene expression biclusters with key missing genes

Determining influential miRNA targets in diseases using influence diffusion model

Identification of candidate regulatory SNPs by integrative analysis for prostate cancer genome data

A data assurance model for syndromic monitoring infectious diseases in developing countries

SAME: a sampling-based multi-locus epistasis algorithm for quantitative genetic trait prediction

expHTS: analysis of high throughput sequence data in an experimental framework

A maximum-likelihood approach to absolute protein quantification in mass spectrometry

A comprehensive analysis of classification algorithms for cancer prediction from gene expression

A deep framework for bacterial image segmentation and classification

An exploratory graph query interface for biomedical data

A frequency-filtering strategy of obtaining PHI-free sentences from clinical data repository

Using motion planning to rank ligand binding affinity

Fast and efficient compression of high-throughput sequencing reads

eClaim System based on IHE XDR

CNVScan: detecting borderline copy number variations in NGS data via scan statistics

Sequential parallel LASSO models for eQTL analysis

Chromatin and genomic determinants of alternative splicing

From gigabyte to kilobyte: a bioinformatics protocol for mining large RNA-Seq transcriptomics data

Compare local pocket and global protein structure models by small structure patterns

MULTICOM: a large-scale conformation sampling and evaluation server for protein tertiary structure prediction

Molecular tweeting: unveiling the social network behind heterogeneous bacteria populations

Do specialized distributed frameworks for bioinformatics applications obtain better performance over generic ones?

Assessing the collective disease association of multiple genomic loci

Application of a systematic exoproteogenomic profiling workflow on lactobacillus mucosae LM1

Improving personalized clinical risk prediction based on causality-based association rules

Consolidated CDA-based care record summary definition and HIE system tools

Developing robust predictive models for head and neck cancer across microarray and RNA-seq data

Investigating genome similarity through cross mapping percentage

An ensemble SVM model for the accurate prediction of non-canonical MicroRNA targets

Detection and tracking of T cells in time-lapse imaging

EDISON: a web application for computational health informatics at scale

Modeling ebola outbreak: a case study on 2014 outbreak in sierra leone

A systems biology approach for the identification of significantly perturbed genes

Greedy topological sorting on questionnaire directed acyclic graph and its application in patient surveys

Ontology-based deep learning for human behavior prediction in health social networks

Data everywhere: an integrated longitudinal data visualization platform for health and demographic surveillance sites

Persistent phylogeny: a galled-tree and integer linear programming approach

Arrhythmia classification using nearest neighbor search with principal component analysis

Ensemble multiple sequence alignment via advising

Structural analysis of PTM hotspots (SAPH-ire): a tool for the prediction of regulatory post-translational modification elements in protein families

The impact of RNA-seq aligners on gene expression estimation

An extensible software infrastructure for testing the evolutionary consequences of developmental interactions

fMRI image registration with AFNI's 3dQwarp

Bone disease prediction and phenotype discovery using feature representation over electronic health records

Content Provider	ACM Digital Library
Author	Li, Xiaoyi Ramanathan, Murali Li, Hui Zhang, Aidong Jia, Xiaowei
Abstract	With the expansion of the healthcare industry and the overwhelming amount of electronic health records (EHRs) shared by healthcare institutions and practitioners, we now wish to take advantage of EHR data to develop an effective disease risk management model that not only improve disease prediction but also shows clinically meaningful feature grouping which can be used to define the bone disease phenotypes. In this paper, we explore the feasibility of extracting critical risk factors for osteoporosis and bone fracture prediction based on heterogeneous electronic health records (EHRs). This will improve our understanding of bone disease risk arising from the complex interplay of the human bone mineral density (BMD) assessment with major risk factors such as gender, age, family history, and life styles. We focus on addressing the problem of identifying individual or integrated risk factors (RFs) to predict osteoporosis and bone fractures, which are common diseases associated with aging and may be clinically silent but cause significant mortality and morbidity. On the other hand, the unbiased, EHR-driven phenotype discovery could be achieved using a massive EHR dataset and a computationally intense analysis capable of identifying all of the phenotypes in the dataset. We infer the precise phenotypic patterns from the new feature representation from EHR data for grouping risk factors for osteoporosis. We present a 2-layer deep graphical model to use EHR with minimal human supervision which derives a new representation of medical objects by embedding them in a low-dimensional vector space. This new low-dimensional risk factor representation will ultimately present the risk factor embedding/clustering by offering intuitive visualization by projection onto a 2D plane. We demonstrate the capability of our framework on a 9704 Caucasian women of 20 years of prospective dataset under osteoporosis and bone fracture assessment. The integrated representation not only improves the risk prediction accuracy but also presents clinically meaningful risk factor grouping for bone diseases.
Starting Page	212
Ending Page	221
Page Count	10
File Format	PDF
ISBN	9781450338530
DOI	10.1145/2808719.2808741
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2015-09-09
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Osteoporosis Bone fracture Phenotyping Deep belief net (dbn) Feature representation Electronic health records Health informatics
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in