NDLI: Multi-level structural domain-domain interactions for prediction of obligate and non-obligate protein-protein interactions

Content Provider	ACM Digital Library
Author	Maleki, Mina Rueda, Luis Hall, Michael
Abstract	The prediction of particular types of protein-protein interactions (PPIs) based on knowledge of their interacting domains is a problem that has drawn the attention of researchers in the past few years. We focus on the prediction and analysis of obligate and nonobligate complexes by using structural domains from the CATH database. Our proposed prediction model is an extension of the one used in our previous work, which uses desolvation energies of domain-domain interactions (DDIs) present in the interfaces of such complexes. The prediction is performed via a support vector machine (SVM). Whereas previous efforts have considered structural domains taken from each level of the CATH hierarchy, in turn, we generalize this to allow some domains to be considered at one level of the hierarchy, while others may be considered at a different level. Our results show an improvement of 4.58% and 2.36% on two well-known datasets over our previous results.
Starting Page	518
Ending Page	520
Page Count	3
File Format	PDF
ISBN	9781450316705
DOI	10.1145/2382936.2383007
Language	English
Publisher	Association for Computing Machinery (ACM)
Publisher Date	2012-10-07
Publisher Place	New York
Access Restriction	Subscribed
Subject Keyword	Complex type prediction Domain-domain interaction Protein-protein interaction
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Multi-level structural domain-domain interactions for prediction of obligate and non-obligate protein-protein interactions