NDLI: Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.

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Year: 2009 Volume: 182 Issue: 6

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Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jacobi, Barbara Eltzschig, Holger K. Schittenhelm, Jens Henn, Martina Hart, Melanie L.
Description	Country affiliation: Germany Author Affiliation: Hart ML ( Department of Anesthesiology and Intensive Care Medicine, Center for Inflammation and Hypoxia, University of Tübingen, Germany.)
Abstract	Gastrointestinal ischemia/reperfusion (IR) injury significantly contributes to the morbidity and mortality of critical illness. In this study, we hypothesized a protective role for extracellular adenosine signaling in intestinal IR injury. Initial profiling studies of mucosal scrapings following murine IR demonstrated selective induction of the A2B adenosine receptor (A2BAR) transcript. Moreover, gene-targeted mice for the A2BAR showed more profound intestinal IR injury compared with controls. In contrast, A2AAR(-/-) mice exhibited no differences in intestinal injury compared with littermate controls. In addition, selective inhibition of the A2BAR resulted in enhanced intestinal inflammation and injury during IR. Furthermore, A2BAR agonist treatment (BAY 60-6583) protected from intestinal injury, inflammation, and permeability dysfunction in wild-type mice, whereas the therapeutic effects of BAY 60-6583 were abolished following targeted A2BAR gene deletion. Taken together, these studies demonstrate the A2BAR as a novel therapeutic target for protection during gastrointestinal IR injury.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	7
Volume Number	182
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2009-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Intestines Metabolism Receptor, Adenosine A2b Reperfusion Injury Signal Transduction Physiology Aminopyridines Pharmacology Animals Blotting, Western Gene Expression Profiling Inflammation Pathology Drug Effects Mice Mice, Knockout Rna, Messenger Genetics Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.

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Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.