NDLI: Characterization of IL-17A-producing cells in celiac disease mucosa.

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Characterization of IL-17A-producing cells in celiac disease mucosa.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	MacDonald, Thomas T. Pallone, Francesco Fina, Daniele Del Vecchio Blanco, Giovanna Monteleone, Ivan Paoluzi, Omero Alessandro Fabrizi, Alessia Franzè, Eleonora Monteleone, Giovanni Sarra, Massimiliano
Description	Country affiliation: Italy Author Affiliation: Monteleone I ( Dipartimento di Medicina Interna, Università Tor Vergata, Rome, Italy.)
Abstract	Celiac disease (CD) is a gluten-sensitive enteropathy associated with a marked infiltration of the mucosa with IFN-gamma-secreting Th1 cells. Recent studies have shown that a novel subset of T cells characterized by expression of high levels of IL-17A, termed Th17 cells, may be responsible for pathogenic effects previously attributed to Th1 cells. In this study, we characterized the expression of IL-17A-producing cells in CD. By real-time PCR and ELISA, it was shown that expression of IL-17A RNA and protein is more pronounced in active CD biopsy specimens in comparison with inactive CD and normal mucosal biopsy specimens. Flow cytometry confirmed that IL-17A is overproduced in CD mucosa and that CD4(+) and CD4(+)CD8(+) cells were major sources. The majority of IL-17A-producing CD4(+) and CD4(+)CD8(+) cells coexpressed IFN-gamma but not CD161. The addition of a peptic-tryptic digest of gliadin to ex vivo organ cultures of duodenal biopsy specimens taken from inactive CD patients enhanced IL-17A production by both CD4(+) and CD4(+)CD8(+) cells. Because we previously showed that IL-21, a T cell-derived cytokine involved in the control of Th17 cell responses, is overproduced in CD, we next assessed whether IL-17A expression is regulated by IL-21. Blockade of IL-21 activity by a neutralizing IL-21 Ab reduced IL-17A expression in cultures of active CD and peptic-tryptic digest of gliadin-treated CD biopsy specimens. In conclusion, our data show that IL-17A is increased in CD and is produced by cells that also make IFN-gamma.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	4
Volume Number	184
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-02-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Celiac Disease Immunology Pathology Interleukin-17 Biosynthesis Intestinal Mucosa Cd4-positive T-lymphocytes Metabolism Cd8-positive T-lymphocytes Duodenum Gene Expression Regulation Inflammation Mediators Physiology Interferon-gamma Antagonists & Inhibitors Genetics Interleukins Organ Culture Techniques Up-regulation Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Characterization of IL-17A-producing cells in celiac disease mucosa.

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