NDLI: Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Napolitani, Giorgio Rizzetto, Lisa De Filippo, Carlotta Kuka, Mirela Torcia, Maria Gabriella D'Oro, Ugo Beltrame, Luca Netea, Mihai G. Cambi, Alessandra Cavalieri, Duccio
Description	Country affiliation: Italy Author Affiliation: Rizzetto L ( Department of Preclinic and Clinic Pharmacology, University of Firenze, Firenze, Italy.)
Abstract	In this study, we present evidence of differential Th17 responses in human monocyte-derived dendritic cells exposed to the pathogenic Candida albicans or the nonpathogenic Saccharomyces cerevisiae. We use different forms of the microorganisms, cells, hyphae, and spores, as a toolbox to dissect the role of surface mannan in the fungal immune response. In contrast to the S. cerevisiae yeast cell-induced Th1 response, dendritic cells stimulated with spores or C. albicans hyphae induce cellular responses shifted toward Th17 differentiation. The differential recognition of specific mannan structures is the master regulator of the discrimination between harmful and harmless fungi. The switch between spores and yeast is crucial for the commensalism of S. cerevisiae and depends on the use of a different receptor repertoire. Understanding the role of cell wall recognition during infection might lead to understanding the boundaries between safety and pathogenicity.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	8
Volume Number	184
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-04-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Candida Albicans Immunology Pathogenicity Interleukin-17 Biosynthesis Mannans Metabolism Saccharomyces Cerevisiae Cd4-positive T-lymphocytes Microbiology Growth & Development Carbohydrate Conformation Cell Differentiation Cell Wall Chemistry Dendritic Cells Cytology Hyphae Interleukin-12 Physiology Monocytes Spores, Fungal Th1 Cells Comparative Study Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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