NDLI: Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis.

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Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis.

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Coronin 1-mediated naive T cell survival is essential for the development of autoimmune encephalomyelitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Siegmund, Kerstin Rolink, Ton Pieters, Jean Schaeren-Wiemers, Nicole Zeis, Thomas Kunz, Gabriele
Description	Country affiliation: Switzerland Author Affiliation: Siegmund K ( Biozentrum, University of Basel, Basel, Switzerland.)
Abstract	Autoimmune encephalomyelitis is a disease of the CNS that can develop when an initial peripheral inflammatory stimulus is followed by infiltration and reactivation of T lymphocytes in the CNS. We report a crucial role for coronin 1, which is essential for maintenance of the naive T cell pool, for the development of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. In the absence of coronin 1, immunization with myelin oligoglycoprotein (MOG(35-55)) peptide largely failed to induce EAE symptoms, despite normal mobilization of leukocyte subsets in the blood, as well as effector cytokine expression comparable with wild-type T cells on polyclonal stimulation. Susceptibility of coronin 1-deficient mice to EAE induction was restored by transfer of wild-type CD4(+) T cells, suggesting that the observed resistance of coronin 1-deficient mice to EAE development is T cell intrinsic. Importantly, although coronin 1-deficient regulatory T cells (Tregs) showed a suppressor activity comparable with wild-type Tregs, Treg depletion failed to restore EAE development in coronin 1-deficient animals. These results suggest a hitherto unrecognized role of naive T cells in the development of autoimmune encephalomyelitis and reveal coronin 1 as a crucial modulator of EAE induction.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	186
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2011-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Encephalomyelitis, Autoimmune, Experimental Immunology Metabolism Microfilament Proteins Physiology T-lymphocyte Subsets Adoptive Transfer Animals Cd4-positive T-lymphocytes Transplantation Cell Survival Genetics Pathology Epitopes, T-lymphocyte Administration & Dosage Mice Mice, Inbred C57bl Mice, Knockout Deficiency Myelin Basic Protein G0 Phase Cytology Comparative Study Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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