NDLI: Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response.

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Invariant NKT cells producing IL-4 or IL-10, but not IFN-gamma, inhibit the Th1 response in experimental autoimmune encephalomyelitis, whereas none of these cells inhibits the Th17 response.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Oh, Sae Jin Chung, Doo Hyun
Description	Author Affiliation: Oh SJ ( Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea.)
Abstract	Experimental autoimmune encephalomyelitis (EAE) is mediated by Th1 and Th17 cells. Invariant NKT (iNKT) cells prevent EAE in an IL-4-, IL-10-, and IFN-Î³-dependent manner. However, which of the iNKT cell-produced cytokines regulates the Th1 or Th17 response in EAE remains unclear. Wild-type B6 and J 18(-/-) mice were immunized with MOG(35-55) peptide to address this issue. Clinical scores for EAE, IL-17, and IFN-Î³ transcript levels, and IL-17- or IFN-Î³-expressing CD4(+) T cell percentages in the CNS and draining lymph nodes were higher in J 18(-/-) than in B6 mice, but all of these parameters in the CNS were reduced by the adoptive transfer of wild-type or IFN-Î³-deficient iNKT cells into the J 18(-/-) mice before immunization. In contrast, adoptive transfer of IL-4- or IL-10-deficient iNKT cells into J 18(-/-) mice decreased IL-17 transcript levels and the percentage of IL-17-expressing CD4(+) T cells in the CNS but did not affect clinical scores, IFN-Î³ transcript levels, or the percentage of IFN-Î³-expressing CD4(+) T cells in the CNS. Taken together, IL-4- and IL-10-producing iNKT cells inhibit the Th1 cell response, but not the Th17 cell response, although wild-type iNKT cells suppress both the Th1 and Th17 responses in the CNS during EAE. Moreover, IFN-Î³-producing iNKT cells have a minimal role in the regulation of the Th1 and Th17 responses in EAE.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	186
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2011-06-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytokines Biosynthesis Encephalomyelitis, Autoimmune, Experimental Immunology Interleukin-10 Interleukin-4 Natural Killer T-cells Metabolism Th1 Cells Th17 Cells Animals Central Nervous System Interferon-gamma Mice Mice, Knockout Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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