NDLI: Alloantibodies against MHC class I: a novel mechanism of neonatal pancytopenia linked to vaccination.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Trumel, Catherine Foucras, Gilles Pichereaux, Carole Lacroux, Caroline Franchi, Cyrielle Burlet-Schiltz, Odile Caubet, Cécile Schelcher, François Tasca, Christian Corbière, Fabien
Description	Country affiliation: France Author Affiliation: Foucras G ( Université de Toulouse, Institut National Polytechnique de Toulouse, Ecole Nationale Vétérinaire de Toulouse, F-31076 Toulouse, France. g.foucras@envt.fr)
Abstract	Fetal/neonatal alloimmune thrombocytopenia is a frequent disease in humans where alloantibodies against platelet Ags lead to platelet destruction and hemorrhage. Although a role in the disease for Abs against MHC has been suspected, this has not been formally demonstrated. Since 2007, a hemorrhagic syndrome due to thrombocytopenia and designated as bovine neonatal pancytopenia (BNP) has been recognized in calves in several European countries. An inactivated antiviral vaccine is strongly suspected to be involved in this syndrome because of its highly frequent use in the dams of affected calves. In this study, we show that BNP is an alloimmune disease, as we reproduced the signs by transferring serum Abs from vaccinated BNP dams into healthy neonatal calves. Ab specificity was strongly associated with the presence of allogeneic MHC class I Abs in the dams. MHC class I staining was also observed on Madin-Darby bovine kidney cells, a cell line related to the one used to produce the vaccine Ag. Our report emphatically demonstrates that alloimmunization against MHC class I is associated with a substantial risk of developing cytopenia-associated syndromes in neonates when a cell line of the same species is used to produce an inactivated vaccine injected into the mother.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	187
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2011-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bovine Virus Diarrhea-mucosal Disease Immunology Cattle Diseases Histocompatibility Antigens Class I Isoantibodies Adverse Effects Pancytopenia Viral Vaccines Administration & Dosage Animals Animals, Newborn Cell Line Diarrhea Viruses, Bovine Viral Gene Knockdown Techniques Immunoglobulin G Leukopenia Thrombocytopenia Vaccines, Inactivated Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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