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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cookenham, Tres Sell, Stewart Woodland, David L. Blackman, Marcia A. Roberts, Alan D. Brincks, Erik L. Kohlmeier, Jacob E. |
| Description | Country affiliation: United States Author Affiliation: Brincks EL ( Trudeau Institute, Saranac Lake, NY 12983, USA.) |
| Abstract | Regulatory CD4(+)Foxp3(+) T cells (Tregs) are key regulators of inflammatory responses and control the magnitude of cellular immune responses to viral infections. However, little is known about how Tregs contribute to immune regulation during memory responses to previously encountered pathogens. In this study, we used MHC class II tetramers specific for the 311-325 peptide from influenza nucleoprotein (NP311-325/IA(b)) to track the Ag-specific Treg response to primary and secondary influenza virus infections. During secondary infections, Ag-specific memory Tregs showed accelerated accumulation in the lung-draining lymph node and lung parenchyma relative to a primary infection. Memory Tregs effectively controlled the in vitro proliferation of memory CD8(+) cells in an Ag-specific fashion that was MHC class II dependent. When memory Tregs were depleted before secondary infection, the magnitude of the Ag-specific memory CD8(+) T cell response was increased, as was pulmonary inflammation and airway cytokine/chemokine expression. Replacement of memory Tregs with naive Tregs failed to restore the regulation of the memory CD8 T cell response during secondary infection. Together, these data demonstrate the existence of a previously undescribed population of Ag-specific memory Tregs that shape the cellular immune response to secondary influenza virus challenges and offer an additional parameter to consider when determining the efficacy of vaccinations. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1203140 |
| Journal | The Journal of Immunology |
| Issue Number | 7 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens Immunology Immunologic Memory Influenza A Virus Orthomyxoviridae Infections T-lymphocytes, Regulatory Animals Antigens, Cd4 Metabolism Cd8-positive T-lymphocytes Epitopes, T-lymphocyte Forkhead Transcription Factors Histocompatibility Antigens Class Ii Inflammation Virology Lung Lymph Nodes Lymphocyte Activation Mice Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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