NDLI: Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2013 Volume: 190 Issue: 12

Year: 2013 Volume: 190 Issue: 11

Year: 2013 Volume: 190 Issue: 10

Year: 2013 Volume: 190 Issue: 9

Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis.

Inflammatory response of mast cells during influenza A virus infection is mediated by active infection and RIG-I signaling.

In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-vs.-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor

MyD88 signaling in CD4 T cells promotes IFN-Î³ production and hematopoietic progenitor cell expansion in response to intracellular bacterial infection.

Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.

NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity.

Transition from heterotypic to homotypic PDK1 homodimerization is essential for TCR-mediated NF-κB activation.

Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation.

Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.

Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia.

CRTAM receptor engagement by Necl-2 on tumor cells triggers cell death of activated VÎ³9VÎ´2 T cells.

IL7R contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.

IL-27 receptor signalling regulates $CD4^{+}$ T cell chemotactic responses during infection

Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.

Prenatally acquired vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model.

GITR-dependent regulation of 4-1BB expression: implications for T cell memory and anti-4-1BB-induced pathology.

Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria.

Role of fatty-acid synthesis in dendritic cell generation and function.

Nonstereotyped lymphoma B cell receptors recognize vimentin as a shared autoantigen.

Tolerogenic Donor-Derived Dendritic Cells Risk Sensitization In Vivo owing to Processing and Presentation by Recipient APCs.

Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma.

Mast cell FcÎµRI-induced early growth response 2 regulates CC chemokine ligand 1-dependent CD4+ T cell migration.

Circulating fibrocytes prepare the lung for cancer metastasis by recruiting Ly-6C+ monocytes via CCL2.

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28.

Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.

Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.

Cutting edge: the pathogenicity of IFN-Î³-producing Th17 cells is independent of T-bet.

Differential binding of pyruvate dehydrogenase complex-E2 epitopes by DRB1*08:01 and DRB1*11:01 Is predicted by their structural motifs and correlates with disease risk.

Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin.

Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.

Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation.

Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.

TAK1-JNK axis mediates survival signal through Mcl1 stabilization in activated T cells.

A stimulation-dependent alternate core promoter links lymphotoxin expression with TGF-ß1 and fibroblast growth factor-7 signaling in primary human T cells.

IκBÎ¶ is a transcriptional key regulator of CCL2/MCP-1.

Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets.

Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine.

Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes.

B cell activation is regulated by the stiffness properties of the substrate presenting the antigens.

Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.

Connexin43 is dispensable for phagocytosis.

Efficient attenuation of NK cell-mediated liver injury through genetically manipulating multiple immunogenes by using a liver-directed vector.

NK cell tolerance of self-specific activating receptor KIR2DS1 in individuals with cognate HLA-C2 ligand.

Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.

Comment on 'A20 and CYLD do not share significant overlapping functions during B cell development and activation'.

Comment on 'helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans'.

Response to comment on 'helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans'.

T Cell Memory: without Prompting.

Integrin Regulation during Leukocyte Recruitment.

Innate immunity and its regulation by mast cells.

Year: 2013 Volume: 190 Issue: 8

Year: 2013 Volume: 190 Issue: 7

Year: 2013 Volume: 190 Issue: 6

Year: 2013 Volume: 190 Issue: 5

Year: 2013 Volume: 190 Issue: 4

Year: 2013 Volume: 190 Issue: 3

Year: 2013 Volume: 190 Issue: 2

Year: 2013 Volume: 190 Issue: 1

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gratz, Iris K. Lee, Karim Rosenblum, Michael D. Yang, Sara Hsin-Yi Truong, Hong-An Abbas, Abul K. Maurano, Megan M.
Description	Country affiliation: United States Author Affiliation: Gratz IK ( Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.)
Abstract	Thymic Foxp3-expressing regulatory T cells are activated by peripheral self-antigen to increase their suppressive function, and a fraction of these cells survive as memory regulatory T cells (mTregs). mTregs persist in nonlymphoid tissue after cessation of Ag expression and have enhanced capacity to suppress tissue-specific autoimmunity. In this study, we show that murine mTregs express specific effector memory T cell markers and localize preferentially to hair follicles in skin. Memory Tregs express high levels of both IL-2R and IL-7R . Using a genetic-deletion approach, we show that IL-2 is required to generate mTregs from naive CD4(+) T cell precursors in vivo. However, IL-2 is not required to maintain these cells in the skin and skin-draining lymph nodes. Conversely, IL-7 is essential for maintaining mTregs in skin in the steady state. These results elucidate the fundamental biology of mTregs and show that IL-7 plays an important role in their survival in skin.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1300212
Journal	The Journal of Immunology
Issue Number	9
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Immunologic Memory Immunology Interleukin-2 Receptor Alpha Subunit Receptors, Interleukin-7 T-lymphocytes, Regulatory Animals Antigens Autoimmunity Cd4-positive T-lymphocytes Hair Follicle Lymph Nodes Mice Mice, Inbred Balb C Skin Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in