NDLI: The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.

Please wait, while we are loading the content...

The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages.

Differential involvement of Th1 and Th17 in pathogenic autoimmune processes triggered by different TLR ligands.

LIGHT (TNFSF14/CD258) is a decisive factor for recovery from experimental autoimmune encephalomyelitis.

Endogenous galectin-1 exerts tonic inhibition on experimental arthritis.

Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and function.

Leishmania-infected MHC class IIhigh dendritic cells polarize CD4+ T cells toward a nonprotective T-bet+ IFN-Î³+ IL-10+ phenotype.

CD166/ALCAM Mediates Proinflammatory Effects of S100B in Delayed Type Hypersensitivity

Inhibition of histone deacetylase activity suppresses IFN-Î³ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1.

Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation.

Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice.

Ectopic expression of epidermal antigens renders the lung a target organ in paraneoplastic pemphigus.

Antibody-secreting cells with a phenotype of Ki-67low, CD138high, CD31high, and CD38high secrete nonspecific IgM during primary hepatitis A virus infection.

GILZ overexpression inhibits endothelial cell adhesive function through regulation of NF-κB and MAPK activity.

MAPK kinase 3 potentiates Chlamydia HSP60-induced inflammatory response through distinct activation of NF-κB.

Myeloid hypoxia-inducible factor-1 is essential for skeletal muscle regeneration in mice.

Role of high endothelial venule-expressed heparan sulfate in chemokine presentation and lymphocyte homing.

Structural evaluation of a mimicry-recognizing paratope: plasticity in antigen-antibody interactions manifests in molecular mimicry.

Dormant Mycobacterium tuberculosis fails to block phagosome maturation and shows unexpected capacity to stimulate specific human T lymphocytes.

Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection.

Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.

Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus.

Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2RÎ³null mouse model.

Cyclooxygenase-2 deficiency in macrophages leads to defective p110Î³ PI3K signaling and impairs cell adhesion and migration.

The IL-33/ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis.

Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy.

Optimal Germinal Center B cell Activation and T-dependent Antibody Responses Require the Expression of the Mouse Complement Receptor Cr1

The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.

Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance.

Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells.

FoxO1 controls effector-to-memory transition and maintenance of functional CD8 T cell memory.

Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.

Unconventional RORÎ³t+ T cells drive hepatic ischemia reperfusion injury.

Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.

Independent expansion of epitope-specific plasma cell responses upon HIV-1 envelope glycoprotein immunization.

Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human VÎ´3 T cells.

Synergistic expression of the CXCL10 gene in response to IL-1ß and IFN-Î³ involves NF-κB, phosphorylation of STAT1 at Tyr701, and acetylation of histones H3 and H4.

Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs.

Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.

Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcÎ³R antagonists that inhibit IgG-mediated effector functions.

Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation.

Working to fill the boss's shoes.

Genome engineering with Cre-loxP.

Reciprocal relationship between myeloid-derived suppressor cells and T cells.

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mendoza, Jason P. Karandikar, Nitin J. Kashi, Venkatesh P. Ortega, Sterling B. Tyler, Andrew F. Cunnusamy, Khrishen
Description	Country affiliation: United States Author Affiliation: Ortega SB ( Department of Pathology, University of Texas Southwestern Medical Center, Dallas TX 75390, USA.)
Abstract	Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS, and CD8 T cells are the predominant T cell population in MS lesions. Given that transfer of CNS-specific CD8 T cells results in an attenuated clinical demyelinating disease in C57BL/6 mice with immunization-induced experimental autoimmune encephalomyelitis (EAE), we investigated the cellular targets and mechanisms of autoreactive regulatory CD8 T cells. In this study we report that myelin oligodendrocyte glycoprotein peptide (MOG35-55)-induced CD8 T cells could also attenuate adoptively transferred, CD4 T cell-mediated EAE. Whereas CD8(-/-) mice exhibited more severe EAE associated with increased autoreactivity and inflammatory cytokine production by myelin-specific CD4 T cells, this was reversed by adoptive transfer of MOG-specific CD8 T cells. These autoregulatory CD8 T cells required in vivo MHC class Ia (K(b)D(b)) presentation. Interestingly, MOG-specific CD8 T cells could also suppress adoptively induced disease using wild-type MOG35-55-specific CD4 T cells transferred into K(b)D(b-/-) recipient mice, suggesting direct targeting of encephalitogenic CD4 T cells. In vivo trafficking analysis revealed that autoregulatory CD8 T cells are dependent on neuroinflammation for CNS infiltration, and their suppression/cytotoxicity of MOG-specific CD4 T cells is observed both in the periphery and in the CNS. These studies provide important insights into the mechanism of disease suppression mediated by autoreactive CD8 T cells in EAE.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1300452
Journal	The Journal of Immunology
Issue Number	1
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Pathology Cd8-positive T-lymphocytes Encephalomyelitis, Autoimmune, Experimental Prevention & Control Adoptive Transfer Amino Acid Sequence Animals Autoimmune Diseases Transplantation Cells, Cultured Cytotoxicity, Immunologic Mice Mice, Inbred C57bl Mice, Knockout Molecular Sequence Data Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Unique features of naive CD8+ T cell activation by IL-2.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Mycobacterium tuberculosis-Specific $CD8^{+}$ T Cells Require Perforin to Kill Target Cells and Provide Protection In $Vivo^{}$

Plasmacytoid dendritic cells take up opsonized antigen leading to CD4+ and CD8+ T cell activation in vivo.

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.

Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.

A mouse mutant p53 product recognized by CD4+ and CD8+ T cells.

IL-23 drives pathogenic IL-17-producing CD8+ T cells.

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.

Similar Documents

Unique features of naive CD8+ T cell activation by IL-2.

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Mycobacterium tuberculosis-Specific $CD8^{+}$ T Cells Require Perforin to Kill Target Cells and Provide Protection In $Vivo^{}$

Plasmacytoid dendritic cells take up opsonized antigen leading to CD4+ and CD8+ T cell activation in vivo.

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.

Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes.

A mouse mutant p53 product recognized by CD4+ and CD8+ T cells.

IL-23 drives pathogenic IL-17-producing CD8+ T cells.

Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies.

The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis.