NDLI: Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.

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Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.

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Mast cells are dispensable for normal and activin-promoted wound healing and skin carcinogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Werner, Sabine Huber, Marcel Rodewald, Hans-Reimer Antsiferova, Maria Martin, Caroline Förster, Anja Feyerabend, Thorsten B. Hohl, Daniel Hartmann, Karin
Description	Author Affiliation: Antsiferova M ( Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich, 8093 Zürich, Switzerland)
Abstract	The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single- and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Activins Pharmacology Carcinoma, Squamous Cell Pathology Mast Cells Physiology Papilloma Skin Neoplasms Wound Healing Drug Effects 9,10-dimethyl-1,2-benzanthracene Administration & Dosage Deficiency Animals Carcinogens Blood Supply Chemically Induced Chemotaxis Injections, Intralesional Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Neovascularization, Pathologic Neutrophil Infiltration Proto-oncogene Proteins C-kit Recombinant Proteins Skin Injuries Tetradecanoylphorbol Acetate Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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