NDLI: Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

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Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Smith, Norah L. Davenport, Miles P. Pinello, Jennifer F. Rudd, Brian D. Wang, Jocelyn Grimson, Andrew Wissink, Erin
Description	Author Affiliation: Smith NL ( Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853); Wissink E ( Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853); Wang J ( Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853); Pinello JF ( Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853); Davenport MP ( Complex Systems in Biology Group, Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia.); Grimson A ( Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853); Rudd BD ( Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853)
Abstract	Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. In this article, we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. Whereas adult CD8+ T cells differentiated into a heterogeneous pool of effector and memory cells, neonatal CD8+ T cells preferentially gave rise to short-lived effector cells and exhibited a distinct gene expression profile. Surprisingly, impaired neonatal memory formation was not due to a lack of responsiveness, but instead because neonatal CD8+ T cells expanded more rapidly than adult cells and quickly became terminally differentiated. Collectively, these findings demonstrate that neonatal CD8+ T cells exhibit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of memory CD8+ T cells in early life.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400553
Journal	The Journal of Immunology
Issue Number	1
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Cell Differentiation Cell Proliferation Immunologic Memory Physiology Animals Genetics Mice Mice, Transgenic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation.

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Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.

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Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.