NDLI: Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.

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Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Yuanyuan Marches, Florentina Merad, Miriam Toshiyuki, Hori Metang, Patrick Banchereau, Jacques Becker, Christian Palucka, A. Karolina Yu, Chun I.
Description	Author Affiliation: Yu CI ( Baylor Institute for Immunology Research, Dallas, TX 75204); Becker C ( Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029); Metang P ( Baylor Institute for Immunology Research, Dallas, TX 75204); Marches F ( Baylor Institute for Immunology Research, Dallas, TX 75204); Wang Y ( Baylor Institute for Immunology Research, Dallas, TX 75204); Toshiyuki H ( College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan); Banchereau J ( The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030); Merad M ( Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029); Palucka AK ( Baylor Institute for Immunology Research, Dallas, TX 75204)
Abstract	Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-Î³. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401159
Journal	The Journal of Immunology
Issue Number	9
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Surface Metabolism Cd4-positive T-lymphocytes Immunology Cytokines Biosynthesis Dendritic Cells Animals Antigens, Cd1 Antigens, Cd40 Cytology Cell Differentiation Cells, Cultured Glycoproteins Immunophenotyping Lung Virology Lymphocyte Activation Mice Mice, Knockout Ox40 Ligand Orthomyxoviridae Phenotype Signal Transduction Th2 Cells Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

CD1a expression defines an interleukin-12 producing population of human dendritic cells.

Correction: Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines

Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells.

Human langerhans cells are more efficient than CD14(-)CD1c(+) dermal dendritic cells at priming naive CD4(+) T cells.

Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L.

Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice.

Monocyte-derived dendritic cells from patients with severe forms of chromoblastomycosis induce CD4+ T cell activation in vitro.

CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules.

Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.

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Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

CD1a expression defines an interleukin-12 producing population of human dendritic cells.

Correction: Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines

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Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.