NDLI: Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.

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Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Forslund, Elin Schaffer, Marie Ask, Eivind Heggernes Malmberg, Karl-Johan Andersson, Sandra Abrahamsen, Greger Spurkland, Anne Enqvist, Monika Önfelt, Björn Béziat, Vivien Bryceson, Yenan Carlsten, Mattias
Description	Author Affiliation: Enqvist M ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Ask EH ( K.G. Jebsen Center for Cancer Immunotherapy, Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway); Forslund E ( Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden); Carlsten M ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Abrahamsen G ( Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway); Béziat V ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Andersson S ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Schaffer M ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Spurkland A ( Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway); Bryceson Y ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden); Önfelt B ( Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden); Malmberg KJ ( Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, 141 86 Stockholm, Sweden)
Abstract	The functional capacity of NK cells is dynamically tuned by integrated signals from inhibitory and activating cell surface receptors in a process termed NK cell education. However, the understanding of the cellular and molecular mechanisms behind this functional tuning is limited. In this study, we show that the expression of the adhesion molecule and activation receptor DNAX accessory molecule 1 (DNAM-1) correlates with the quantity and quality of the inhibitory input by HLA class I-specific killer cell Ig-like receptors and CD94/NKG2A as well as with the magnitude of functional responses. Upon target cell recognition, the conformational state of LFA-1 changed in educated NK cells, associated with rapid colocalization of both active LFA-1 and DNAM-1 at the immune synapse. Thus, the coordinated expression of LFA-1 and DNAM-1 is a central component of NK cell education and provides a potential mechanism for controlling cytotoxicity by functionally mature NK cells.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Differentiation, T-lymphocyte Genetics Gene Expression Killer Cells, Natural Immunology Metabolism Lymphocyte Function-associated Antigen-1 Biological Markers Immunological Synapses Receptors, Natural Killer Cell Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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