NDLI: The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.

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The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gannagé, Monique Brilot, Fabienne Fonteneau, Jean Francois Münz, Christian
Description	Author Affiliation: Fonteneau JF ( INSERM UMR892, CNRS UMR6299, Université de Nantes, Nantes 44007, France); Brilot F ( Neuroimmunology Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital at Westmead, St. Westmead, New South Wales 2145, Australia); Münz C ( Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich 8006, Switzerland); Gannagé M ( Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich 8006, Switzerland)
Abstract	NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag processing for MHC class II presentation. In contrast, intercellular Ag transfer, followed by classical MHC class II Ag processing via endocytosis, sensitized neighboring melanoma cells for CD4(+) T cell recognition. However, macroautophagy targeting of NY-ESO-1 enhanced MHC class II presentation. Therefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell recognition by CD4(+) T cells and should be explored during immunotherapy of melanoma.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1402664
Journal	The Journal of Immunology
Issue Number	1
Volume Number	196
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2016-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Neoplasm Immunology Cd4-positive T-lymphocytes Transplantation Immunotherapy, Adoptive Melanoma Therapy Membrane Proteins Acetylcysteine Analogs & Derivatives Pharmacology Antigen Presentation Autophagy Cell Line, Tumor Chloroquine Dendritic Cells Endocytosis Epitopes, T-lymphocyte Histocompatibility Antigens Class Ii Leupeptins Lymphocyte Activation Lysosomal-associated Membrane Protein 2 Genetics Rna Interference Rna, Small Interfering Small Ubiquitin-related Modifier Proteins Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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