NDLI: Serial assessment of serum bone metabolism markers identifies women with the highest rate of bone loss and osteoporosis risk.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Väänänen, H. Kalervo Gerdhem, Paul Akesson, Kristina Ivaska, Kaisa K. Lenora, Janaka Obrant, Karl J.
Description	Country affiliation: Sweden Author Affiliation: Ivaska KK ( Clinical and Molecular Osteoporosis Research Unit, Department of Orthopaedics, Malmö University Hospital, Malmö, Sweden. kaisa.ivaska@med.lu.se)
Abstract	CONTEXT: One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures. OBJECTIVE: Our objective was to evaluate whether assessment of bone metabolism at multiple occasions can identify women with the highest risk for bone loss. DESIGN: The Malmö Osteoporosis Prospective Risk Assessment study is an ongoing longitudinal study. Participants have been evaluated at baseline and after 1, 3, and 5 yr. SETTING: We conducted a population-based study. PARTICIPANTS: Participants included 1044 women, all 75 yr old at baseline. MAIN OUTCOME MEASURES: Seven bone turnover markers were assessed at baseline and at 1, 3, and 5 yr (n = 573). The 5-yr change in areal bone mineral density (aBMD) was also determined. RESULTS: Baseline markers correlated weakly to change in total body aBMD. The associations were more pronounced when the average of the baseline and 1-yr measurements was used (standardized regression coefficients -0.12 to -0.23, P < 0.01). Adding the 3-yr and 5-yr measurement further strengthened the correlation (regression coefficients up to -0.30, P < 0.001). Women with constantly high turnover lost significantly more bone at total body assessment (-2.6%) than women with intermediate (-1.6%) or low turnover (-0.2%, P for trend < 0.001). They also had a greater decrease in hip BMD (-8.3, -6.0, and -5.1%, respectively, P = 0.010). Results were similar also in the subgroup of women with osteopenia. CONCLUSIONS: Our results suggest that serial assessment of bone turnover improves the identification of women with the highest rate of bone loss and osteoporosis risk.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	7
Volume Number	93
Language	English
Publisher	Oxford University Press
Publisher Date	2008-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone Diseases, Metabolic Diagnosis Bone And Bones Metabolism Osteoporosis, Postmenopausal Biological Markers Bone Density Bone Remodeling Longitudinal Studies Research Support, Non-u.s. Gov't Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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